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Table 1 Integrative pathway enrichment analysis results of DNA methylation and mRNA expression profiles between KBD and OA cartilage

From: Integrating genome-wide DNA methylation and mRNA expression profiles identified different molecular features between Kashin-Beck disease and primary osteoarthritis

Pathway name KEGG ID P value No. of significantly different genes* No. of genes in KEGG pathway
Adherens junction path:hsa04520 5.34 × 10−3 5 60
Insulin secretion path:hsa04911 7.32 × 10–3 5 65
Other types of O-glycan biosynthesis path:hsa00514 0.010 3 24
Pathways in cancer path:hsa05200 0.015 10 247
Pancreatic cancer path:hsa05212 0.016 4 52
Chronic myeloid leukemia path:hsa05220 0.017 4 53
Valine, leucine and isoleucine biosynthesis path:hsa00290 0.020 1 4
Type II diabetes mellitus path:hsa04930 0.021 3 32
PI3K-Akt signaling pathway path:hsa04151 0.024 9 233
Glycosaminoglycan biosynthesis—keratan sulfate path:hsa00533 0.028 2 14
mTOR signaling pathway path:hsa04150 0.030 3 37
Nicotinate and nicotinamide metabolism path:hsa00760 0.031 2 15
Osteoclast differentiation path:hsa04380 0.033 5 99
Glycosaminoglycan biosynthesis—chondroitin sulfate/dermatan sulfate path:hsa00532 0.039 2 17
Transcriptional misregulation in cancer path:hsa05202 0.041 6 143
Acute myeloid leukemia path:hsa05221 0.047 3 45
Vascular smooth muscle contraction path:hsa04270 0.048 4 77
Chagas disease (American trypanosomiasis) path:hsa05142 0.048 4 77
Insulin signaling pathway path:hsa04910 0.049 4 78
  1. KEGG Kyoto Encyclopedia of Genes and Genomes, mTOR mammalian target of rapamycin, PI3K phosphatidylinositol 3’-kinase
  2. * Number of genes differently expressed and methylated in Kashin-Beck disease (KBD) compared with osteoarthritis (OA) within the given pathway