Fig. 7

Effect of CR6086 administration compared with naproxen in arthritic mice (collagen-induced arthritis [CIA] model). Arthritis was induced by intradermal injection of bovine type II collagen in complete Freund’s adjuvant as described in the Methods section of the main text. Upon arthritis onset, animals were randomised into experimental groups. Drugs were administered orally once daily for 10 days. a Box-and-whisker plots and median of the histological scores for the signal limb of each mouse under the protocol described in the Methods section of the main text. ^bP < 0.001, ^cP < 0.01, ^dP < 0.05 vs vehicle-treated rats by Kruskal-Wallis test followed by Dunn’s test for multiple comparisons. b Effect of 30 and 60 mg/kg oral administration of CR6086, and 60 mg/kg naproxen, on interleukin (IL)-6 concentration in sera of arthritic mice at the end of treatment. a ≠ b P < 0.05 by one-way analysis of variance followed by Dunnett’s test