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Table 1 Mechanical hyperalgesia: effect of repeated administration of CR6086 and rofecoxib in arthritic rats (collagen-induced arthritis model)

From: Pharmacological characterisation of CR6086, a potent prostaglandin E2 receptor 4 antagonist, as a new potential disease-modifying anti-rheumatic drug

 

Day 0 (gram-force)

Day 7 (gram-force)

Day 14 (gram-force)

Sham

1174.59 ± 48.41

1040.32 ± 53.38

1074.66 ± 45.60

Vehicle

894.81 ± 69.51a

666.79 ± 49.15b

600.42 ± 50.23b

15 mg/kg CR6086

850.45 ± 59.57a

846.33 ± 43.60b,c

1023.09 ± 53.97d

15 mg/kg rofecoxib

943.70 ± 73.42a

673.18 ± 53.76b

799.68 ± 61.15b,c

  1. Results are reported as mean ± SEM for each group
  2. aP < 0.05 vs sham rats
  3. bP < 0.001 vs sham rats
  4. cP < 0.05 vs vehicle-treated arthritic rats (one-way analysis of variance [ANOVA] followed by multiple comparisons test)
  5. dP < 0.001 vs vehicle-treated arthritic rats (one-way ANOVA followed by multiple comparisons test)