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Table 2 Fluorescence-activated cell sorting analysis of cell populations in the joint

From: Pharmacological characterisation of CR6086, a potent prostaglandin E2 receptor 4 antagonist, as a new potential disease-modifying anti-rheumatic drug

Cell population

Percentage of total cells

Vehicle

Etanercept

CR6086

Naproxen

Th1

0.32 ± 0.03

0.20 ± 0.05a

0.14 ± 0.03b

0.35 ± 0.07

Th17

0.20 ± 0.03

0.16 ± 0.08

0.06 ± 0.01b

0.21 ± 0.08

Treg

0.54 ± 0.12

0.39 ± 0.10

0.38 ± 0.12

0.63 ± 0.22

B cells

5.00 ± 0.53

5.74 ± 0.68

6.65 ± 0.72

5.77 ± 1.16

Neutrophils

19.04 ± 4.23

10.53 ± 2.81

9.98 ± 2.89a

16.47 ± 4.48

Macrophages

20.81 ± 4.44

12.31 ± 5.19

11.14 ± 2.93a

16.31 ± 4.44

Dendritic cells

2.31 ± 0.62

1.51 ± 0.18

1.72 ± 0.44

1.96 ± 0.48

  1. Th T-helper cell, Treg Regulatory T cell
  2. Results are reported as mean percentage ± SEM in each group
  3. aP < 0.05 vs collagen-induced arthritis (CIA) mice treated with vehicle by paired two-tailed t test
  4. bP < 0.01 vs CIA mice treated with vehicle by paired two-tailed t test