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Table 1 Demographics and imaging characteristics at T0

From: Exploring determinants predicting response to intra-articular hyaluronic acid treatment in symptomatic knee osteoarthritis: 9-year follow-up data from the Osteoarthritis Initiative

 

Total (n = 404)a

Low,b0 < WOMAC painc < 4(n = 118)

Moderate,4 ≤ WOMAC painc ≤ 7(n = 150)

High,WOMAC painc ≥ 8(n = 136)

Low vs Highp valued

Moderate vs Highp valued

Subcohort

 Incidence

47% (189)

54% (64)

50% (75)

37% (50)

  

 Progression

53% (215)

46% (54)

50% (75)

63% (86)

0.005 e

0.024 e

Injected knee

 Right

50% (204)

51% (60)

51% (76)

50% (68)

  

 Left

50% (200)

49% (58)

49% (74)

50% (68)

0.893e

0.910e

Sex, male

41% (165)

46% (54)

43% (65)

34% (46)

0.052e

0.099e

Age (years)

66 ± 9

66 ± 9

66 ± 9

64 ± 9

0.140

0.190

 

(n = 364)

(n = 110)

(n = 134)

(n = 120)

  

Body mass index

30.39 ± 5.30

28.98 ± 4.48

30.74 ± 4.99

31.30 ± 6.07

0.002

0.353

Kellgren–Lawrence

(n = 208)

(n = 62)

(n = 78)

(n = 68)

  

 Grade 0, 1

15% (31)

23% (14)

14% (11)

9% (6)

  

 Grade 2

26% (55)

29% (18)

26% (20)

25% (17)

  

 Grade 3

35% (72)

32% (20)

33% (26)

38% (26)

  

 Grade 4

24% (50)

16% (10)

27% (21)

28% (19)

0.088e

0.769e

 

(n = 226)

(n = 67)

(n = 86)

(n = 73)

  

Joint space width (mm)

3.34 ± 1.62

3.78 ± 1.79

3.23 ± 1.57

3.06 ± 1.45

0.010

0.430

Magnetic resonance imaging

 Cartilage volume (mm3)

(n = 239)

(n = 69)

(n = 92)

(n = 78)

  

  Global knee

9371 ± 2788

10,196 ± 2356

9060 ± 2959

9009 ± 2813

0.002

0.917

  Medial compartment

4351 ± 1615

4861 ± 1515

4093 ± 1644

4205 ± 1582

0.008

0.670

  Lateral compartment

5020 ± 1490

5335 ± 1209

4967 ± 1627

4805 ± 1519

0.009

0.760

 Bone marrow lesion (global knee)

(n = 246)

(n = 73)

(n = 92)

(n = 81)

  

  Presence

42% (104)

44% (32)

36% (33)

48% (39)

0.592e

0.102e

  Score

1.97 ± 3.37

1.54 ± 2.54

1.86 ± 3.95

2.49 ± 3.28

0.090

0.058

 Medial meniscus

(n = 248)

(n = 74)

(n = 95)

(n = 79)

  

  No extrusion

64% (159)

68% (50)

67% (64)

57% (45)

  

  Extrusion

36% (89)

32% (24)

33% (31)

43% (34)

0.177e

0.158e

 

(n = 231)

(n = 67)

(n = 87)

(n = 77)

  

 Synovial fluid volume (ml)

20.12 ± 13.59

17.43 ± 11.46

19.77 ± 13.25

22.86 ± 15.22

0.033

0.203

  1. Results are shown as mean ± standard deviation or % and number (n) of participants’ IAHA injected knees. Bold data are significant at p < 0.05
  2. T0 visit before IAHA treatment, IAHA intra-articular hyaluronic acid, WOMAC Western Ontario and McMaster Universities Osteoarthritis Index
  3. aNumber of injected knees based on 310 participants
  4. bThe level of pain on the WOMAC score was divided into three groups (Low, Moderate, and High) based on tertile analysis
  5. cWOMAC Likert 3.1 (scale 0–20) pain scores at T0. Participants with WOMAC pain score = 0 were excluded from analysis
  6. dContinuous variables were compared using Student’s t test/Mann–Whitney test
  7. eProportions compared using the chi-squared test/Fisher’s exact test