Total (n = 404)a | Low,b0 < WOMAC painc < 4(n = 118) | Moderate,4 ≤ WOMAC painc ≤ 7(n = 150) | High,WOMAC painc ≥ 8(n = 136) | Low vs Highp valued | Moderate vs Highp valued | |
---|---|---|---|---|---|---|
Subcohort | ||||||
Incidence | 47% (189) | 54% (64) | 50% (75) | 37% (50) | ||
Progression | 53% (215) | 46% (54) | 50% (75) | 63% (86) | 0.005 e | 0.024 e |
Injected knee | ||||||
Right | 50% (204) | 51% (60) | 51% (76) | 50% (68) | ||
Left | 50% (200) | 49% (58) | 49% (74) | 50% (68) | 0.893e | 0.910e |
Sex, male | 41% (165) | 46% (54) | 43% (65) | 34% (46) | 0.052e | 0.099e |
Age (years) | 66 ± 9 | 66 ± 9 | 66 ± 9 | 64 ± 9 | 0.140 | 0.190 |
(n = 364) | (n = 110) | (n = 134) | (n = 120) | |||
Body mass index | 30.39 ± 5.30 | 28.98 ± 4.48 | 30.74 ± 4.99 | 31.30 ± 6.07 | 0.002 | 0.353 |
Kellgren–Lawrence | (n = 208) | (n = 62) | (n = 78) | (n = 68) | ||
Grade 0, 1 | 15% (31) | 23% (14) | 14% (11) | 9% (6) | ||
Grade 2 | 26% (55) | 29% (18) | 26% (20) | 25% (17) | ||
Grade 3 | 35% (72) | 32% (20) | 33% (26) | 38% (26) | ||
Grade 4 | 24% (50) | 16% (10) | 27% (21) | 28% (19) | 0.088e | 0.769e |
(n = 226) | (n = 67) | (n = 86) | (n = 73) | |||
Joint space width (mm) | 3.34 ± 1.62 | 3.78 ± 1.79 | 3.23 ± 1.57 | 3.06 ± 1.45 | 0.010 | 0.430 |
Magnetic resonance imaging | ||||||
Cartilage volume (mm3) | (n = 239) | (n = 69) | (n = 92) | (n = 78) | ||
Global knee | 9371 ± 2788 | 10,196 ± 2356 | 9060 ± 2959 | 9009 ± 2813 | 0.002 | 0.917 |
Medial compartment | 4351 ± 1615 | 4861 ± 1515 | 4093 ± 1644 | 4205 ± 1582 | 0.008 | 0.670 |
Lateral compartment | 5020 ± 1490 | 5335 ± 1209 | 4967 ± 1627 | 4805 ± 1519 | 0.009 | 0.760 |
Bone marrow lesion (global knee) | (n = 246) | (n = 73) | (n = 92) | (n = 81) | ||
Presence | 42% (104) | 44% (32) | 36% (33) | 48% (39) | 0.592e | 0.102e |
Score | 1.97 ± 3.37 | 1.54 ± 2.54 | 1.86 ± 3.95 | 2.49 ± 3.28 | 0.090 | 0.058 |
Medial meniscus | (n = 248) | (n = 74) | (n = 95) | (n = 79) | ||
No extrusion | 64% (159) | 68% (50) | 67% (64) | 57% (45) | ||
Extrusion | 36% (89) | 32% (24) | 33% (31) | 43% (34) | 0.177e | 0.158e |
(n = 231) | (n = 67) | (n = 87) | (n = 77) | |||
Synovial fluid volume (ml) | 20.12 ± 13.59 | 17.43 ± 11.46 | 19.77 ± 13.25 | 22.86 ± 15.22 | 0.033 | 0.203 |