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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Hypogalactosylation of immunoglobulin G in rheumatoid arthritis: relationship to HLA-DRB1 shared epitope, anticitrullinated protein antibodies, rheumatoid factor, and correlation with inflammatory activity

Fig. 1

Immunoglobulin G (IgG) N-glycan structure and analysis. Composition of N-glycan structures attached to IgG. N-glycans share a common pentasaccharide core consisting of two N-acetylglucosamines (GlcNAc) and three mannose residues (gray background). Major structures are represented by agalactosylated IgG (G0), monogalactosylated IgG (G1), and digalactosylated IgG (G2) glycoforms. Above, a representative capillary electrophoresis laser-induced fluorescence detection electropherogram of fragment crystallizable region of IgG N-glycans is shown. F Core fucose, Ax Number of antennary GlcNAc, B Bisecting GlcNAc linking beta 1–4 to beta 1–3 mannose, Gx Number of beta 1–4 linked galactose (G), [3]G1 and [6]G1 galactose on antenna of alpha 1–3 or alpha 1–6 mannose, respectively, Sx Number of N-acetylneuraminic acids linked to galactose, GU Glucose units

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