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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Hypogalactosylation of immunoglobulin G in rheumatoid arthritis: relationship to HLA-DRB1 shared epitope, anticitrullinated protein antibodies, rheumatoid factor, and correlation with inflammatory activity

Fig. 6

Immunoglobulin G (IgG) galactosylation in rheumatoid arthritis (RA), stratified by anticitrullinated protein antibody (ACPA), rheumatoid factor (RF) and human leukocyte antigen (HLA)-DRB1 shared epitope (SE) status. Comparison of agalactosylated immunoglobulin G/monogalactosylated immunoglobulin G (G0/G1) ratios in RA subsets defined by ACPA, RF, and HLA-DRB1 SE status. a IgG G0/G1 ratios in RA subsets defined by ACPA, RF, or SE status. b IgG G0/G1 ratios of RA subsets defined combinations of SE and ACPA status. c IgG G0/G1 ratios of RA subsets defined by combinations of SE and RF status. Horizontal lines indicate the median of distribution. p Values derived by Mann-Whitney U tests are indicated. In regard to multiple testing, a Bonferroni-corrected p value of p < 0.0042 should be applied. axSpA Axial spondyloarthritis, HC Healthy control subjects

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