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Fig. 8 | Arthritis Research & Therapy

Fig. 8

From: Hypogalactosylation of immunoglobulin G in rheumatoid arthritis: relationship to HLA-DRB1 shared epitope, anticitrullinated protein antibodies, rheumatoid factor, and correlation with inflammatory activity

Fig. 8

Correlation of immunoglobulin G (IgG) hypogalactosylation with disease activity in patients with rheumatoid arthritis (RA), stratified by human leukocyte antigen (HLA)-DRB1 shared epitope (SE), anticitrullinated protein antibody (ACPA), or rheumatoid factor (RF) status. Relationship between IgG agalactosylated immunoglobulin G/monogalactosylated immunoglobulin G (G0/G1) ratio and activity markers (Disease Activity Score in 28 joints [DAS28], C-reactive protein [CRP], and erythrocyte sedimentation rate [ESR]) in RA. Analyses for strata defined by HLA-DRB1 SE (a–c), ACPA (d–f), and RF (g–i) status. Results of regression analyses and 95% CIs are given, as well as p values for heterogeneity. Sex is indicated by upright triangles (female) and inverted triangles (male). In regard to multiple testing, a Bonferroni-corrected p value of p < 0.0042 should be applied

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