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Table 1 Correlations between anti-CXCR3 and anti-CXCR4 antibody levels and lung function parameters in systemic sclerosis patients

From: Antibodies against chemokine receptors CXCR3 and CXCR4 predict progressive deterioration of lung function in patients with systemic sclerosis

Lung function parameter

Anti-CXCR3

Anti-CXCR4

SRT-r

p values

n

SRT-r

p values

n

VC (%)

–0.50

≤ 0.001

71

−0.43

≤ 0.001

58

FVC (%)

−0.27

≤ 0.001

284

−0.2

≤ 0.001

271

TLC (%)

−0.25

≤ 0.001

253

−0.21

≤ 0.001

240

DLCO-SB (%)

−0.32

≤ 0.01

274

−0.26

≤ 0.05

64

DLCO/VA (%)

−0.20

= 0.08

245

−0.16

= 0.20

64

FEV1 (%)

–0.18

≤ 0.01

278

−0.17

≤ 0.01

265

FEV1/VC (%)

+0.25

≤ 0.05

71

+0.2

= 0.13

58

  1. R values of Spearman’s rho (SRT-r) as well as p values are shown
  2. Vital capacity (VC), forced vital capacity (FVC), total lung capacity (TLC), the diffusing capacity for carbon monoxide (DLCO) measured by a single breath (DLCO-SB), DLCO/VA, forced expiratory volume in 1 s (FEV1), and Tiffeneau index (FEV1/VC) are given