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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Traditional Chinese medicine formula Bi-Qi capsule alleviates rheumatoid arthritis-induced inflammation, synovial hyperplasia, and cartilage destruction in rats

Fig. 3

Bi-Qi capsule (BQ) or methotrexate (MTX) reduced collagen-induced arthritis (CIA)-induced osteopontin (OPN) and cartilage oligomeric matrix protein (COMP) upregulation in serum, and mRNA and protein levels in paw joint tissue. a, b OPN and COMP levels in serum. c, d OPN and COMP mRNA expression in paw joint cartilage. e, f OPN and COMP protein quantification from immunohistochemistry images of paw joint synovium. Data are presented as mean ± SD from eight rats in each group. Significant effect of treatment compared to control: *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Significant effect of treatment compared to arthritic group: ####P < 0.0001. Significant effect of treatment compared to high-dose BQ (BQ-HD): $$P < 0.01, $$$$P < 0.0001. Significant effect of treatment compared to MTX-group: &P < 0.05, &&&&P < 0.0001. BQ-MD, moderate-dose BQ

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