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Table 1 Clinical characteristics of patients at enrollment

From: Interleukin-37 is increased in adult-onset Still’s disease and associated with disease activity

  AOSD (n = 62)  
Active (n = 41) Inactive (n = 21) HC (n = 50)
Age, years 43.4 ± 14.1 37.5 ± 14.2 38.6 ± 11.7
Sex, F/M 31/10 15/6 37/13
Duration, months 2.4 ± 2.7 13.7 ± 13.0  
Clinical features
 Fever 38 (92.7) 0  
 Sore throat 30 (73.2) 0  
 Skin rash 32 (78.0) 2 (9.5)  
 Lymphadenopathy 30 (73.2) 2 (9.5)  
 Splenomegaly 15 (36.6) 0  
 Hepatomegaly 1 (2.4) 0  
 Pericarditis 8 (19.5) 0  
 Pleuritis 10 (24.4) 0  
 Myalgia 14 (34.1) 0  
 Arthralgia 37 (90.2) 0  
 Arthritis 17 (41.5) 1 (4.8)  
 Systemic score 6.9 ± 2.0 0.2 ± 0.5  
Laboratory markers
 Hemoglobin, g/L 110.2 ± 25.8 130.0 ± 16.5  
 Leukocytes, 109/L 17.0 ± 5.5 8.1 ± 2.5  
 Platelets, 109/L 285.7 ± 119.6 248.9 ± 74.9  
 ESR, mm/h 73.2 ± 27.1 17.0 ± 27.9  
 CRP, mg/L 91.5 ± 54.8 13.5 ± 16.6  
 ALT, U/L 63.1 ± 58.9 27.1 ± 12.0  
 AST, U/L 49.1 ± 20.1 31.1 ± 10.3  
 Ferritin, ng/ml 9665.2 ± 4692.7 181.8 ± 162.6
 ANA positivity 6 (14.6) 1 (4.8)  
 RF positivity 2 (4.9) 0  
Treatments
 Steroid- and sDMARD-naïve 41 (100) 2a (9.5)  
 Low-dose steroid monotherapy 0 0  
 High-dose steroid monotherapy 0 0  
 sDMARD(s) 0 6 (28.6)  
 Combination therapy, steroids + sDMARD(s) 0 13 (61.9)  
  1. Abbreviations: AOSD Adult-onset Still’s disease, HC Healthy control, ESR Erythrocyte sedimentation rate, CRP C-reactive protein, AST Aspartate transaminase, ALT Alanine transaminase, ANA Antinuclear antibody, RF Rheumatoid factor, sDMARD Synthetic disease-modifying antirheumatic drug
  2. Low dose of steroids was defined as ≤ 0.5 mg/kg/day of prednisone; high dose of steroids was defined as > 0.5 mg/kg/day of prednisone
  3. All values are presented as number (percent) or mean ± SD
  4. aDrug withdrawal