Table 1 Clinical characteristics of patients at enrollment
From: Interleukin-37 is increased in adult-onset Still’s disease and associated with disease activity
AOSD (n = 62) | |||
|---|---|---|---|
Active (n = 41) | Inactive (n = 21) | HC (n = 50) | |
Age, years | 43.4 ± 14.1 | 37.5 ± 14.2 | 38.6 ± 11.7 |
Sex, F/M | 31/10 | 15/6 | 37/13 |
Duration, months | 2.4 ± 2.7 | 13.7 ± 13.0 | |
Clinical features | |||
Fever | 38 (92.7) | 0 | |
Sore throat | 30 (73.2) | 0 | |
Skin rash | 32 (78.0) | 2 (9.5) | |
Lymphadenopathy | 30 (73.2) | 2 (9.5) | |
Splenomegaly | 15 (36.6) | 0 | |
Hepatomegaly | 1 (2.4) | 0 | |
Pericarditis | 8 (19.5) | 0 | |
Pleuritis | 10 (24.4) | 0 | |
Myalgia | 14 (34.1) | 0 | |
Arthralgia | 37 (90.2) | 0 | |
Arthritis | 17 (41.5) | 1 (4.8) | |
Systemic score | 6.9 ± 2.0 | 0.2 ± 0.5 | |
Laboratory markers | |||
Hemoglobin, g/L | 110.2 ± 25.8 | 130.0 ± 16.5 | |
Leukocytes, 109/L | 17.0 ± 5.5 | 8.1 ± 2.5 | |
Platelets, 109/L | 285.7 ± 119.6 | 248.9 ± 74.9 | |
ESR, mm/h | 73.2 ± 27.1 | 17.0 ± 27.9 | |
CRP, mg/L | 91.5 ± 54.8 | 13.5 ± 16.6 | |
ALT, U/L | 63.1 ± 58.9 | 27.1 ± 12.0 | |
AST, U/L | 49.1 ± 20.1 | 31.1 ± 10.3 | |
Ferritin, ng/ml | 9665.2 ± 4692.7 | 181.8 ± 162.6 | |
ANA positivity | 6 (14.6) | 1 (4.8) | |
RF positivity | 2 (4.9) | 0 | |
Treatments | |||
Steroid- and sDMARD-naïve | 41 (100) | 2a (9.5) | |
Low-dose steroid monotherapy | 0 | 0 | |
High-dose steroid monotherapy | 0 | 0 | |
sDMARD(s) | 0 | 6 (28.6) | |
Combination therapy, steroids + sDMARD(s) | 0 | 13 (61.9) | |