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Table 3 Comparison of the serum IL-37 levels according to disease manifestations in 62 patients with adult-onset Still’s disease

From: Interleukin-37 is increased in adult-onset Still’s disease and associated with disease activity

Manifestations

Serum IL-37 levels

P value

Fever

(+), n = 38

428.42 ± 291.40

0.0003

(−), n = 24

165.33 ± 221.06

 

Sore throat

(+), n = 30

419.32 ± 294.61

0.0127

(−), n = 32

239.64 ± 270.42

 

Skin rash

(+), n = 34

416.33 ± 308.19

0.0041

(−), n = 28

217.60 ± 239.06

 

Lymphadenopathy

(+), n = 32

436.64 ± 288.01

0.0005

(−), n = 30

209.18 ± 256.72

 

Hepatomegaly

(+), n = 1

156.63

0.7586

(−), n = 61

329.37 ± 295.93

 

Splenomegaly

(+), n = 15

477.52 ± 311.97

0.015

(−), n = 47

278.41 ± 274.67

 

Pericarditis

(+), n = 8

432.69 ± 301.64

0.1824

(−), n = 54

310.86 ± 292.79

 

Pneumonia

(+), n = 20

379.57 ± 310.59

0.3544

(−), n = 42

301.34 ± 286.62

 

Pleuritis

(+), n = 10

479.63 ± 336.37

0.0978

(−), n = 52

297.15 ± 279.57

 

Myalgia

(+), n = 14

449.08 ± 222.11

0.0211

(−), n = 48

290.85 ± 304.96

 

Arthritis

(+), n = 18

427.91 ± 324.91

0.1068

(−), n = 44

285.13 ± 274.02

 

Arthralgia

(+), n = 38

405.41 ± 297.41

0.0026

(−), n = 24

201.77 ± 246.81

 
  1. IL Interleukin
  2. Serum IL-37 levels are shown as mean ± SD, and differences between two groups were analyzed using the Mann-Whitney U test for nonparametric data