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Table 3 Comparison of the serum IL-37 levels according to disease manifestations in 62 patients with adult-onset Still’s disease

From: Interleukin-37 is increased in adult-onset Still’s disease and associated with disease activity

Manifestations Serum IL-37 levels P value
Fever (+), n = 38 428.42 ± 291.40 0.0003
(−), n = 24 165.33 ± 221.06  
Sore throat (+), n = 30 419.32 ± 294.61 0.0127
(−), n = 32 239.64 ± 270.42  
Skin rash (+), n = 34 416.33 ± 308.19 0.0041
(−), n = 28 217.60 ± 239.06  
Lymphadenopathy (+), n = 32 436.64 ± 288.01 0.0005
(−), n = 30 209.18 ± 256.72  
Hepatomegaly (+), n = 1 156.63 0.7586
(−), n = 61 329.37 ± 295.93  
Splenomegaly (+), n = 15 477.52 ± 311.97 0.015
(−), n = 47 278.41 ± 274.67  
Pericarditis (+), n = 8 432.69 ± 301.64 0.1824
(−), n = 54 310.86 ± 292.79  
Pneumonia (+), n = 20 379.57 ± 310.59 0.3544
(−), n = 42 301.34 ± 286.62  
Pleuritis (+), n = 10 479.63 ± 336.37 0.0978
(−), n = 52 297.15 ± 279.57  
Myalgia (+), n = 14 449.08 ± 222.11 0.0211
(−), n = 48 290.85 ± 304.96  
Arthritis (+), n = 18 427.91 ± 324.91 0.1068
(−), n = 44 285.13 ± 274.02  
Arthralgia (+), n = 38 405.41 ± 297.41 0.0026
(−), n = 24 201.77 ± 246.81  
  1. IL Interleukin
  2. Serum IL-37 levels are shown as mean ± SD, and differences between two groups were analyzed using the Mann-Whitney U test for nonparametric data