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Table 4 Interaction analysis for incident gout by risk factor using three different approaches

From: Untangling the complex relationships between incident gout risk, serum urate, and its comorbidities

 

One interactiona

 

Full regressionb

 

Stepwisec

 
 

Est. (OR)

p Value

Est. (OR)

p Value

Est. (OR)

p Value

Main effects

   

Serum urate, (mg/dl)

-

-

0.846 (2.33)

<0.001

0.794 (2.21)

<0.001

Ethnicity: AA

-

-

1.622 (5.06)

0.025

0.624 (1.87)

<0.001

SBP: Hypertensive

-

-

0.529 (1.70)

0.579

0.486 (1.63)

0.008

Interactions

   

SU: Ethnicity AA

-0.130 (0.88)

0.156

-0.130 (0.88)

0.16

-

-

SU: SBP Hypertensive

-0.026 (0.97)

0.833

-0.007 (0.99)

0.955

-

-

  1. aDerived from a logistic regression of gout on main effects plus one interaction term. The main effect estimates were not printed because they depended on which interaction was included
  2. bDerived from a logistic regression of gout on all main effects and the two interactions listed in rows
  3. cDerived from a stepwise logistic regression that minimized either AIC or BIC Rows with ‘-’ correspond to predictors that were not selected by the stepwise procedure Bold cells indicate effect estimates that were statistically different than zero at 0.01 significance level
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Arthritis Research & Therapy

ISSN: 1478-6362

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