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Table 4 Interaction analysis for incident gout by risk factor using three different approaches

From: Untangling the complex relationships between incident gout risk, serum urate, and its comorbidities

  One interactiona   Full regressionb   Stepwisec  
  Est. (OR) p Value Est. (OR) p Value Est. (OR) p Value
Main effects    
Serum urate, (mg/dl) - - 0.846 (2.33) <0.001 0.794 (2.21) <0.001
Ethnicity: AA - - 1.622 (5.06) 0.025 0.624 (1.87) <0.001
SBP: Hypertensive - - 0.529 (1.70) 0.579 0.486 (1.63) 0.008
Interactions    
SU: Ethnicity AA -0.130 (0.88) 0.156 -0.130 (0.88) 0.16 - -
SU: SBP Hypertensive -0.026 (0.97) 0.833 -0.007 (0.99) 0.955 - -
  1. aDerived from a logistic regression of gout on main effects plus one interaction term. The main effect estimates were not printed because they depended on which interaction was included
  2. bDerived from a logistic regression of gout on all main effects and the two interactions listed in rows
  3. cDerived from a stepwise logistic regression that minimized either AIC or BIC Rows with ‘-’ correspond to predictors that were not selected by the stepwise procedure Bold cells indicate effect estimates that were statistically different than zero at 0.01 significance level