Fig. 3
From: CCL17 blockade as a therapy for osteoarthritis pain and disease
Therapeutic neutralization of chemokine (c-c motif) ligand 17 (CCL17) ameliorates collagenase-induced osteoarthritis (CiOA)-induced pain and arthritis. WT mice were induced with CiOA on day 0 and treated therapeutically from day 20 with PBS, isotype control or anti-CCL17 mAb twice weekly. a Change in weight distribution (pain) over time. b Representative histologic pictures of knee joints (Safranin O/fast green stain, original magnification ×100) and quantification of arthritis at day 42. c Representative histologic pictures of osteophytes (indicated by arrow) (Safranin O/fast green stain; original magnification ×100) and quantification of osteophyte size. Results are expressed as the mean ± SEM; n = 10 mice per strain (from two independent experiments). LT, lateral tibia; LF, lateral femur; MT, medial tibia; MF, medial femur; i.a., intra-articular. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, isotype control vs. anti-CCL17