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Table 4 Relationship between serum citrullinated inter-alpha-trypsin inhibitor heavy chain 4 and rheumatoid factor/anticitrullinated protein antibodies levels in patients with rheumatoid arthritis

From: Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis

 

RF+ ACPA+

RF+ ACPA−

RF− ACPA+

RF− ACPA−

No. of patients (%)

42 (75%)

2 (4%)

4 (7%)

8 (14%)

Cit-ITIH4 level

2.2 ± 0.5

1.3 ± 0.9

0.6 ± 0.3

0.9 ± 0.3

Cit-ITIH4-positive, n (%)

38 (91%)

1 (50%)

1 (25%)

7 (88%)

  1. Abbreviations: Cit-ITIH4 Citrullinated inter-alpha-trypsin inhibitor heavy chain 4, RF Rheumatoid factor, ACPA Anticitrullinated protein antibody
  2. Cit-ITIH4 levels are mean ± SEM of band intensity