From: Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis
RF+ ACPA+
RF+ ACPA−
RF− ACPA+
RF− ACPA−
No. of patients (%)
42 (75%)
2 (4%)
4 (7%)
8 (14%)
Cit-ITIH4 level
2.2 ± 0.5
1.3 ± 0.9
0.6 ± 0.3
0.9 ± 0.3
Cit-ITIH4-positive, n (%)
38 (91%)
1 (50%)
1 (25%)
7 (88%)