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Table 4 Relationship between serum citrullinated inter-alpha-trypsin inhibitor heavy chain 4 and rheumatoid factor/anticitrullinated protein antibodies levels in patients with rheumatoid arthritis

From: Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis

  RF+ ACPA+ RF+ ACPA RF ACPA+ RF ACPA
No. of patients (%) 42 (75%) 2 (4%) 4 (7%) 8 (14%)
Cit-ITIH4 level 2.2 ± 0.5 1.3 ± 0.9 0.6 ± 0.3 0.9 ± 0.3
Cit-ITIH4-positive, n (%) 38 (91%) 1 (50%) 1 (25%) 7 (88%)
  1. Abbreviations: Cit-ITIH4 Citrullinated inter-alpha-trypsin inhibitor heavy chain 4, RF Rheumatoid factor, ACPA Anticitrullinated protein antibody
  2. Cit-ITIH4 levels are mean ± SEM of band intensity