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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Dysregulated heme oxygenase-1low M2-like macrophages augment lupus nephritis via Bach1 induced by type I interferons

Fig. 3

Phenotypic analysis of BTB and CNC homology 1 (Bach1)-deficient MRL/lpr mice. Clinical and renal findings were compared between Bach1+/+ and Bach1−/− MRL/lpr mice as follows. a Kaplan-Meier survival analysis. b Proteinuria (g/g*Cr). c Serum blood urea nitrogen (BUN) (mg/dl) at 24 weeks. d Anti-double-stranded DNA (anti-dsDNA) antibody (Ab) immunoglobulin G (IgG) (U/ml). *p < 0.05 by Student’s t test. n.s. Not significant. Data shown are mean ± SEM. e Immunoblot analysis of Bach1, heme oxygenase (HO)-1, and glyceraldehyde 3-phosphate dehydrogenase (Gapdh) in whole spleens and kidneys

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Arthritis Research & Therapy

ISSN: 1478-6362

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