Fig. 4

The ModuLand algorithm was applied in Cytoscape to inferred and non-inferred interactome networks of differentially abundant proteins (± 1.2-fold change; p ≤ 0.05) between stages I and II of autologous chondrocyte implantation in clinical responders and non-responders. Modules were identified from both non-inferred (protein changes identified from proteomic analysis only) and inferred (identified protein changes and inferred proteins interactions) networks and are ranked on the basis of their hierarchical network connectivity