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Table 1 Demographic data for patient participants whose samples from Stage I or Stage II were analysed who responded clinically (responders) or who did not respond (non-responders) to autologous chondrocyte implantation (ACI)

From: Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation

  Stage I Stage II Mann-Whitney U test p value (A)R v NR- SI; (B) R v NR- SI Mann-Whitney U test p value) (A)SI v SII-R; (B) SI v SII- NR
  Responders (n = 8) Non-responders (n = 7) Responders (n = 12) Non-responders (n = 12)
Difference in Lysholm score 27 (17–38) − 8 (− 4 to − 17) 34 (17–54) − 11 (− 4 to − 46) (A) 0.0003; (B) < 0.0001 (A) 0.21; (B) 0.55
BMI, kg/m2 29 (23–31) 27 (24–31) 27 (23–48) 29 (22–36) (A) 0.94; (B) 0.54 (A) 0.73; (B) 0.68
Age, years 32 (17–49) 40 (25–50) 40 (17–90) 43 (25–52) (A) 0.28; (B) 0.92 (A) 0.17; (B) 0.58
Male/female sex, n 8/0 7/0 11/1 10/2 (A) > 0.99; (B) > 0.99 (A) > 0.99; (B) 0.51
Smoker, n 1 2 1 3 (A) 0.54; (B) 0.59 (A) > 0.99; (B) > 0.99
Dilution factor of SF 5 (3–9) 4 (2–7) 4 (1–9) 3 (2–5) (A) 0.48; (B) 0.25 (A) 0.53; (B) 0.50
Total defect area, cm2 14 (0.4–24) 6 (0.6–12) 6 (1–20) 5 (0.6–12) (A) 0.74; (B) 0.35 (A) 0.45; (B) 0.28
Patella defect, n 1 1 4 2 (A) > 0.99; (B) 0.64 (A) 0.60; (B) > 0.99
LFC defect, n 2 0 0 0 (A) 0.47; (B) > 0.99 (A) 0.15; (B) > 0.99
LTP defect, n 1 0 0 0 (A) > 0.99; (B) > 0.99 (A) 0.15; (B) > 0.99
MFC defect, n 2 2 1 6 (A) > 0.99; (B) 0.07 (A) 0.54; (B) 0.63
Trochlea defect, n 0 3 2 1 (A) 0.20; (B) > 0.99 (A) 0.49; (B) 0.12
Multiple defects, n 1 0 1 1 (A) > 0.99; (B) > 0.99 (A) > 0.99; (B) > 0.99
Unknown defect location, n 1 1 4 2 (A) > 0.99; (B) 0.64 (A) 0.60; (B) > 0.99
  1. Footnote: None of the demographic parameters, other than a difference in Lysholm score, showed differences between responders (R) and non-responders (NR) among individuals whose SF from stage I (SI) or stage II (SII) was compared, nor were there differences between individuals who were either responders or non-responders when we compared stage I and stage II samples (p ≥ 0.05 by Mann-Whitney U test). Data are median (range). Abbreviations: BMI Body mass index, LFC Lateral femoral condyle, LTP Lateral tibial plateau, MFC Medial femoral condyle