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Table 2 Fold change of proteins that are differentially abundant in the synovial fluid of clinical non-responders compared with clinical responders to autologous chondrocyte implantation (ACI) immediately prior to stage I

From: Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation

Protein Fold change Identification method
Description Accession no. LF LC-MS/MS iTRAQ nLC-MS/MS
Complement C1S subcomponent P09871 − 5.15   +
Haptoglobin P00738 − 4.49   +
Mesencephalic astrocyte-derived neurotrophic factor P55145 2.15   +
Plasma protease C1 inhibitor P05155 2.19   +
Immunoglobulin kappa chain V-II region MIL P01615 2.60 +  
Bifunctional glutamate/proline-transfer RNA ligase P07814 2.61   +
Pigment epithelium-derived factor P36955 3.13   +
Apolipoprotein A-IV P06727 3.19   +
Apolipoprotein L1 O14791 3.19   +
N-acetylglucosamine-6-sulphatase P15586 3.25   +
Retinol-binding protein 4 P02753 3.34   +
Inter-alpha-trypsin inhibitor heavy chain H1 P19827 3.37   +
Extracellular matrix protein 1 Q16610 3.77   +
Lumican P51884 3.80   +
Histidine-rich glycoprotein P04196 3.84   +
Endoplasmin P14625 4.37   +
Serum paraoxonase/arylesterase 1 P27169 4.41   +
  1. Footnote: Differential abundance was denoted by greater than or equal to ± 2.0-fold change; p ≤ 0.05; protein identified by at least two unique peptides.  Positive numbers denote higher abundance in non-responders than in responders. Proteins were identified using either protein dynamic compression coupled with label-free quantitation LC-MS/MS or no protein dynamic compression with isobaric tags for absolute and relative quantitation (iTRAQ) LC-MS/MS