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Table 3 Fold change of proteins that are differentially abundant in the synovial fluid of clinical non-responders compared with clinical responders to autologous chondrocyte implantation (ACI) immediately prior to stage II

From: Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation

Protein Fold Change Identification method
Description Accession LF LC-MS/MS iTRAQ nLC-MS/MS
40S Ribosomal protein S14 P62263 − 8.63   +
Kinectin Q86UP2 − 6.20   +
Apolipoprotein C-III P02656 − 2.78   +
High-mobility group protein B1 P09429 − 2.56   +
Kininogen-1 P01042 2.27   +
26S Protease regulatory subunit 7 P35998 2.34 +  
26S Proteasome non-ATPase regulatory subunit 13 Q9UNM6 2.43 +  
Alpha-enolase P06733 2.56   +
Alpha-2-HS-glycoprotein P02765 2.78   +
Hemopexin P02790 2.88   +
Ferritin light chain P02792 2.91 +  
Platelet factor 4 P02776 3.26 +  
Thrombospondin-1 P07996 3.40 +  
Nucleosome assembly protein 1-like 1 P55209 4.94 +  
Cofilin-1 P23528 7.08 +  
EH domain-containing protein 1 Q9H4M9 7.30 +  
Haemoglobin subunit delta P02042 8.09   +
Protein S100-A6 P06703 8.39   +
T-complex protein 1 subunit eta Q99832 8.43 +  
Haemoglobin subunit beta P68871 32.81   +
Haemoglobin subunit alpha P69905 44.06   +
  1. Footnote: Differential abundance was denoted by greater than or equal to ± 2.0-fold change; p ≤ 0.05; protein identified by at least two unique peptides. Positive numbers denote higher abundance in non-responders than in responders. Proteins were identified using either protein dynamic compression coupled with label-free quantitation LC-MS/MS or no protein dynamic compression with isobaric tags for absolute and relative quantitation (iTRAQ) LC-MS/MS