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Table 4 Fold change of proteins that are differentially abundant in the synovial fluid of clinical responders at stage II compared with stage I of autologous chondrocyte implantation (ACI)

From: Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation

Protein

Fold change

Identification method

Description

Accession no.

 

LF LC-MS/MS

iTRAQ nLC-MS/MS

Microtubule-associated protein 1B

P46821

− 20.65

+

 

40S Ribosomal protein S14

P62263

− 16.75

 

+

Protein disulphide-isomerase A6

Q15084

− 7.59

 

+

Nucleolin

P19338

− 5.11

 

+

Histone H1.2

P16403

− 3.84

 

+

Stress-induced-phosphoprotein 1

P31948

− 3.63

 

+

Complement factor D

P00746

− 3.44

 

+

SH3 domain-binding glutamic acid-rich-like protein

O75368

− 3.44

 

+

Heterogeneous nuclear ribonucleoprotein U

Q00839

− 3.40

 

+

78 kDa Glucose-regulated protein

P11021

− 3.25

 

+

Cartilage oligomeric matrix protein

P49747

− 3.10

 

+

Annexin A2

P07335

− 2.96

 

+

Mesencephalic astrocyte-derived neurotrophic factor

P55145

− 2.86

 

+

Kinectin

Q86UP2

− 2.81

 

+

Complement factor H-related protein 3

Q02985

− 2.77

+

 

Phosphatidylethanolamine-binding protein 1

P30086

− 2.51

 

+

Peroxiredoxin-4

Q13162

− 2.49

+

 

Regucalcin

Q15493

− 2.44

 

+

Malate dehydrogenase, mitochondrial

P40926

− 2.44

 

+

N-acetylglucosamine-6-sulphatase

P15586

− 2.31

 

+

Gelsolin

P06396

− 2.27

 

+

Alpha-endosulfine

O43768

− 2.25

 

+

Peptidyl-prolyl cis-trans isomerase FKBP3

Q00688

− 2.11

 

+

Hemopexin

P02790

2.05

 

+

Serum paraoxonase/arylesterase 1

P27169

2.07

 

+

Secreted phosphoprotein 24

Q13103

2.10

+

 

Heparin cofactor 2

P05546

2.13

 

+

Ferritin light chain

P02792

2.21

+

 

Attractin

O75882

2.21

 

+

Ig gamma-2 chain C region

P01859

2.23

 

+

Plasma kallikrein

P03952

2.24

 

+

Chondroitin sulphate proteoglycan 4

Q6UVK1

2.35

+

 

Collagen alpha-2(I) chain

P08123

2.37

+

 

Collagen alpha-1(V) chain

P20908

2.54

+

 

CD5 antigen-like

O43866

2.58

 

+

Phospholipid transfer protein

P55058

2.63

 

+

Insulin-like growth factor-binding protein complex acid labile subunit

P35858

2.68

 

+

Prothrombin

P00734

2.68

 

+

Beta-2-glycoprotein 1

P02749

2.78

 

+

Collagen alpha-2(V) chain

P05997

2.84

+

 

Plasma protease C1 inhibitor

P05155

2.91

 

+

Serum amyloid P component

P02743

2.91

 

+

Complement C1q subcomponent subunit B

P02746

3.01

 

+

Collagen alpha-1(I) chain

P02452

3.05

+

 

Alpha-2-antiplasmin

P08697

3.10

 

+

Alpha-1B-glycoprotein

P04217

3.19

 

+

Complement factor B

P00751

3.25

 

+

Complement component C7

P10643

3.40

 

+

Vitamin K-dependent protein S

P07225

3.42

 

+

Apolipoprotein E

P02649

3.44

 

+

Alpha-1-antichymotrypsin

P01011

3.44

 

+

Carboxypeptidase N subunit 2

P22792

3.53

 

+

Vitronectin

P04004

3.63

 

+

Inter-alpha-trypsin inhibitor heavy chain H3

Q06033

3.66

 

+

Complement C5 O

P01031

4.00

 

+

Plasminogen

P00747

4.06

 

+

Kininogen 1

P01042

4.17

 

+

Platelet factor 4

P02776

4.26

+

 

Inter-alpha-trypsin inhibitor heavy chain H2

P19823

4.49

 

+

Periostin

Q15063

4.57

+

 

Apolipoprotein L1

O14791

4.61

 

+

Protein 4.1

P11171

4.66

+

 

26S Proteasome non-ATPase regulatory subunit 13

Q9UNM6

4.78

+

 

Inter-alpha-trypsin inhibitor heavy chain H1

P19827

5.01

 

+

Inter-alpha-trypsin inhibitor heavy chain H4

Q14624

5.06

 

+

Complement C1r subcomponent

P00736

5.15

 

+

Complement component C6

P13671

5.45

 

+

Complement factor H

P08603

5.50

 

+

Catalase

P04040

5.60

 

+

Ficolin-3

O75636

6.43

 

+

C4b-binding protein alpha chain

P04003

7.05

 

+

Ceruloplasmin

P00450

7.51

 

+

Pregnancy zone protein

P20742

8.09

 

+

Fibrinogen alpha chain

P02671

8.40

 

+

Apolipoprotein M

O95445

9.04

 

+

Protein S100-A6

P06703

9.82

 

+

Haemoglobin subunit alpha

P69905

9.82

 

+

Complement C1s subcomponent

P09871

10.00

 

+

Ig mu chain C region

P01871

12.13

 

+

Haptoglobin

P00738

13.68

 

+

Fibrinogen beta chain

P02675

16.90

 

+

Haemoglobin subunit beta

P68871

19.41

 

+

Fibrinogen gamma chain

P02679

23.55

 

+

  1. Footnote: Differential abundance was denoted by greater than or equal to ± 2.0-fold change; p ≤ 0.05; protein identified by at least two unique peptides. Positive numbers denote higher abundance at stage II than at stage I. Proteins were identified using either protein dynamic compression coupled with label-free quantitation LC-MS/MS or no protein dynamic compression with isobaric tags for absolute and relative quantitation (iTRAQ) LC-MS/MS