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Table 1 Baseline characteristics of the patients with Clinically Suspect Arthralgia (N = 507)

From: Inflammation functions as a key mediator in the link between ACPA and erosion development: an association study in Clinically Suspect Arthralgia

Patient characteristic
 Age in years, mean (SD) 44 (13)
 Female sex, n (%) 390 (77)
 Family history of RA, n (%) 147 (29)
 Symptom duration in weeks, median (IQR) 17 (9–32)
 Presence of morning stiffness ≥60 min, n (%) 182 (36)
 Current smoker, n (%) 137 (27)
 68-TJC, median (IQR) 6 (3–10)
 Increased CRP (≥5 mg/L), n (%) 106 (21)
 Presence of local subclinical joint inflammation, n (%) 255 (50)
 Positive for EULAR definition for arthralgia suspicious for progression to RA [17], n (%) 325 (64)
Autoantibody status
 Negative for IgM-RF and ACPA, n (%) 385 (76)
 IgM-RF-positive (≥3.5 IU/mL), ACPA-negative, n (%) 52 (10)
 ACPA-positive (≥7 U/mL), IgM-RF-negative, n (%) 15 (3)
 IgM-RF-positive and ACPA-positive, n (%) 55 (11)
ACPA-level (U/ml) in ACPA-positive patients, median (IQR) 162 (35–340)
 ACPA-level (U/ml) in ACPA-positive patients without local joint inflammation, median (IQR) 129 (23–340)
 ACPA-level (U/ml) in ACPA-positive patients with local joint inflammation, median (IQR) 191 (38–340)
  1. Local subclinical joint inflammation was identified if the prevalence of magnetic resonance imaging (MRI)-detected bone marrow edema, synovitis or tenosynovitis was higher than that of age-matched symptom-free controls
  2. ACPA anti-citrullinated peptide antibody, CRP C-reactive protein, EULAR European League Against Rheumatism, IgM-RF immunoglobulin M rheumatoid factor, IQR interquartile range, RA rheumatoid arthritis, RF rheumatoid factor, SD standard deviation, TJC tender joint count