Table 1 Baseline clinical and renal pathological features of LN patients with or without deep remission
Baseline characteristics | Deep remission | p | |
|---|---|---|---|
Achieved (n = 55) | Not achieved (n = 14) | ||
Sex (percentage female) | 48 (87.3) | 9 (64.2) | 0.01 |
Age (years) | 39.1 ± 12.4 | 39.9 ± 10.7 | 0.3 |
BMI (kg/m2) | 22.4 ± 3.3 | 20.9 ± 2.3 | 0.5 |
Systolic blood pressure (mmHg) | 127.8 ± 17.0 | 136.4 ± 21.5 | 0.2 |
Diastolic blood pressure | 79.7 ± 13.6 | 83.6 ± 14.5 | 0.3 |
Disease duration (years) | 5.1 ± 6.8 | 8.0 ± 6.4 | 0.4 |
SLEDAI | 15.6 ± 4.8 | 13.0 ± 4.8 | 0.4 |
SDI | 0.4 ± 0.6 | 0.6 ± 0.8 | 0.7 |
Proteinuria (g/gCr) | 2.7 ± 2.1 | 3.7 ± 1.8 | 0.07 |
eGFR (mL/min) | 76.6 ± 28.2 | 72.2 ± 32.8 | 0.9 |
Anti-dsDNA antibody (IU/mL) | 177 ± 274 | 112 ± 116 | 0.6 |
Anti-cardiolipin antibody (IU/mL) | 21.8 ± 30.7 | 14.7 ± 28.5 | 0.5 |
Lupus anticoagulant-positive (%) | 3 (5.5) | 1 (7.1) | 0.6 |
CH50 (U/ml) | 17.1 ± 9.3 | 24.4 ± 14.2 | 0.06 |
Prednisolone (mg/day) | 45.5 ± 15.1 | 37.1 ± 10.1 | 0.08 |
Induction therapy | |||
 IVCY (%) | 29 (52.7) | 5 (35.7) | 0.4 |
 MMF (%) | 8 (14.5) | 2 (14.3) | 0.9 |
 Tacrolimus (%) | 8 (14.5) | 2 (14.3) | 0.9 |
 PSL monotherapy (%) | 6 (10.9) | 2 (14.3) | 0.8 |
 Others (%) | 4 (7.3) | 3 (21.4) | 0.1 |
Renal pathological findings | |||
 ISN/RPS classification | |||
  III or III + V (%) | 26 (47.3) | 5 (35.7) | 0.4 |
  IV or IV + V (%) | 29 (52.7) | 9 (64.3) | 0.4 |
Endocapillary hypercellularity (%) | 39.2 ± 18.6 | 46.0 ± 30.2 | 0.5 |
Leukocyte infiltration (%) | 2.0 ± 4.9 | 2.2 ± 4.1 | 0.4 |
Subendothelial hyaline deposits (%) | 29.1 ± 30.2 | 30.1 ± 28.9 | 0.3 |
Fibrinoid necrosis/karyorrhexis (%) | 7.0 ± 11.1 | 8.1 ± 18.1 | 0.3 |
Cellular crescents (%) | 7.0 ± 11.1 | 8.1 ± 18.1 | 0.7 |
Interstitial inflammation (%) | 2.1 ± 3.7 | 2.3 ± 7.4 | 0.5 |
Glomerular sclerosis (%) | 2.5 ± 7.1 | 3.9 ± 8.2 | 0.4 |
Fibrous crescents (%) | 2.1 ± 2.0 | 2.2 ± 3.1 | 0.7 |
Tubular atrophy (%) | 2.8 ± 4.7 | 3.3 ± 5.9 | 0.5 |
Interstitial fibrosis (%) | 4.7 ± 6.8 | 5.1 ± 5.9 | 0.6 |
Activity index | 5.2 ± 3.0 | 5.1 ± 3.8 | 0.5 |
Chronicity index | 1.4 ± 0.4 | 1.4 ± 1.3 | 0.7 |