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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Effects of selexipag and its active metabolite in contrasting the profibrotic myofibroblast activity in cultured scleroderma skin fibroblasts

Fig. 1

Evaluation of α-smooth muscle actin (α-SMA), type I collagen (COL-1), and fibronectin (FN) in cultured human skin fibroblasts isolated from patients with systemic sclerosis (SSc) and healthy subjects (HSs). a Immunocytochemistry analysis of α-SMA, COL-1 and FN in cultured human SSc and HS skin fibroblasts maintained in normal growth medium without treatment for 48 h. b Immunocytochemistry analysis of α-SMA in cultured human SSc skin fibroblasts maintained in normal growth medium (untreated), treated with selexipag at the concentration of 30 μM, 3 μM, and 0.3 μM, and treated with ACT-333679 at the concentration of 10 μM, 1 μM, and 0.1 μM for 48 h

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