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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus

Fig. 1

Plasma cell/plasmablast-related gene expression is increased at different stages of disease progression to rheumatoid arthritis (RA). RNA-sequencing was performed on biopsies from healthy tissue, and tissue from patients with osteoarthritis (OA), arthralgia, undifferentiated arthritis (UA), early RA and established RA (Est RA). a CD38 expression stratified by disease group/stage. b Transcription factors XBP1, IRF4, and PRDM1 mRNA were measured in synovial biopsies from different disease groups. c Plasma cell/plasmablast survival-related genes IGJ and TNFSF13B expression in synovial biopsies from different disease groups. *Statistically significant difference compared to healthy tissue (all graphs) (adjusted P < 0.05)

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Arthritis Research & Therapy

ISSN: 1478-6362

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