Skip to main content

Table 1 Baseline characteristics stratified by PDQ group

From: The course of pain hypersensitivity according to painDETECT in patients with rheumatoid arthritis initiating treatment: results from the prospective FRAME-cohort study

  PDQ score 7 (5-9) PDQ score 16 (13-18) PDQ score ≥ 19 p value
(n = 66) (n = 23) (n = 12)  
PDQ score 7 (5–9)  16 (13–18) 21 (20–23) <.0001
Female, n (%) 45 (68.2) 20 (87.0) 31 (91.7) 0.09
Age, years (SD) 56.1 (14.7) 54.6 (18.9) 47.4 (15.6) 0.22
Initiated csDMARD, n (%) 37 (78.7) 6 (12.8) 4 (8.5)  
Disease duration, months 15.5 (1–104) 53 (9–47) 34.5 (24–149.5) 0.12
Current smoker, n (%) 11 (16.9) a 7 (30.4) 2 (16.7) 0.39
Corticosteroid usage, n (%) 11 (16.7) 2 (8.7) 3 (25.0) 0.42
28 Swollen joint count 2 (1–7) 5 (2–8) 2 (1–4) 0.09
28 Tender joint count 5 (3–10) 13 (8–16) 9.5 (6.5–15) <.0001
Tender point count, 0–18 6 (4–14) 10 (7–16) 12 (6–14) 0.02
Tender point count ≥11, n (%) 20 (30.3) 11 (47.8) 7 (58.3) 0.09
DAS28 (SD) 4.2 (1.1) 5.0 (1.2) 4.8 (0.7) 0.007†
HAQ-DI, 0–3 0.75 (0.38–1.25) 1.13 (0.88–1.75) 1.63 (1.19–1.88) 0.0004
VAS-fatigue, mm 53.5 (27–71) 75 (52–89) 72.5 (60.5–87) 0.002
VAS-pain, mm 42 (24–60) 69 (50–82) 63 (45.5–80.5) 0.0003
VAS-global health, mm 56 (32–77) 73 (46–85) 78 (61.5–90) 0.03‡
GAD-10 score, 0–50 6 (3–10) a 10 (6–17) 9 (9–12) 0.008
MDI score, 0–50 8 (4–12) a 11 (6–25) 13.5 (9–19.5) 0.01
SF-36 PCS, 0–100 35 (29–42) 33 (26–37) 28 (24–32) 0.02‡
SF-36 MCS, 0–100 51 (40–57) 43 (31–51) 37 (31–49) 0.005
CRP, mg/mL 8 (3–15) 4 (0.5–19) 3 (0.8–8.5) 0.13
IgM-RF positive, n (%) 41 (62.1) 15 (65.2) 8 (66.7) 1.0
Anti-CCP positive, n (%) 46 (70) 15 (65) 7 (58) 0.72
RAMRIS hand synovitis 7 (5–10) 9.5 (7–11) 7 (6–9) 0.18
RAMRIS hand edema 5 (1–10) 9.5 (3–22) 5 (2–13) 0.12
  1. Values are median (25th, 75th percentiles) unless specified otherwise
  2. Unless specified otherwise significant p values reflect difference between PDQ score < 13 and 13–18 and ≥ 19, while there is no difference between PDQ score 13–18 and ≥ 19
  3. Only difference between PDQ score < 13 and 13–18
  4. Only difference between PDQ score < 13 and ≥ 19
  5. RAMRIS hand; wrist+MCP scores
  6. One patient receiving MRI had no corresponding PDQ score. 26 patients did not receive MRI scan. Number of patients (n) for RAMRIS parameters: PDQ score < 13, n = 51; PDQ score 13–18, n = 18; PDQ score > 18, n = 6. (a) One missing observation. (b) Three missing observations