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Table 2 Mean change stratified by baseline PDQ group adjusted for baseline value

From: The course of pain hypersensitivity according to painDETECT in patients with rheumatoid arthritis initiating treatment: results from the prospective FRAME-cohort study

  PDQ score < 13 PDQ score 13–18 PDQ score ≥ 19 p value
(n = 66) (n = 23) (n = 12)
PDQ consistency, N (%) 64 (97) 19 (83) 0 (0) < 0.001
Δ PDQ score −4.10 (−5.74;-2.45) −2.20 (− 4.64;0.25) −5.49(−9.97;-1.02) 0.08
Δ 28 SJC −2.71 (− 3.26;-2.17) − 2.27 (− 3.21;-1.34) − 2.48(− 3.77;-1.19) 0.71
Δ 28 TJC − 4.63(− 5.67;-3.60) −4.36(− 5.14; − 1.58) −5.57(−7.96;-3.18) 0.28
Δ CRP, mg/mL −6.93 (− 8.54;-5.32) −2.81 (− 5.54;-0.08) −6.28 (− 10.10;- 2.47) 0.04a
Δ DAS28-CRP − 1.47 (− 1.74; − 1.20) −0.8(− 1.27;-0.34) −1.62 (− 2.25;-1.00) 0.03b
Δ Tender point count −2.70 (− 3.87;-1.57) −1.56 (− 3.48; 0.36) − 3.83 (− 6.46;-1.20) 0.35
Δ VAS-fatigue −18.31(− 25.55;-13.06) −8.19 (− 17.07; 0.68) −22.20 (− 34.48;-9.91) 0.09
Δ VAS-pain −23.27(− 28.21;-18.33) −12.99(− 21.40;-4.57) −26.86 (− 38.34;-15.38) 0.07
Δ VAS-global health −26.20(− 31.15;-21.25) −13.49 (− 21.83;-5.15) −31.72 (− 43.44;-20.01) 0.01b
Δ HAQ-DI − 0.34 (− 0.44;-0.24) − 0.15 (− 0.32; 0.02) −0.74 (− 0.98;-0.50) < 0.001c
Δ MDI-total − 3.04(− 4.39;-1.68) −2.54 (− 4.83;-0.25) −3.68(− 6.80;-0.55) 0.84
Δ GAD10-total −2.24 (− 3.18;-1.30) −1.56 (− 3.15; 0.02) −2.10 (− 4.27; 0.07) 0.76
Δ SF36-MCS 5.5 (3.34; 7.60) 3.70 (0.09; 7.31) 11.38 (6.40;16.36) 0.04c
Δ SF36-PCS 6.47 (4.39; 8.56) 4.94 (1.43; 8.44) 8.96 (3.97; 13.94) 0.42
Δ RAMRIS H synovitis −1.69 (− 2.32;-1.07) − 1.81(− 2.90,-0.71) −2.47 (− 4.28;-0.66) 0.72
Δ RAMRIS H edema −2.17 (− 4.00;-0.34) − 0.57(− 3.80;2.66) − 3.46 (− 8.72;1.81) 0.58
  1. Values are means (95% CI). Negative numbers indicate improvement. ANCOVA (BOCF) was used for the analyses unless otherwise indicated. †Chi-square test
  2. RAMRIS H hand (W + M). W wrist. M MCP joints
  3. (n) for RAMRIS parameters: PDQ score < 13; n = 51, PDQ score 13–18; n = 18, PDQ score > 18; n = 6. (a) No difference between PDQ score < 13 and > 18, and 13–18 and > 18. (b) No difference between PDQ score < 13 and PDQ score > 18. (c) No difference between PDQ score < 13 and 13–18