The course of pain hypersensitivity according to painDETECT in patients with rheumatoid arthritis initiating treatment: results from the prospective FRAME-cohort study

Table 3 Baseline values and mean changes (adjusted for baseline value) for the exploratory DCE-MRI variables

	PDQ score < 13	PDQ score 13–18	PDQ score ≥ 19	p value
Baseline values
Nvoxel in ml wrist	13.17 (5.53–29.40)	14.78(7.22–25.84)	14.21(8.28–22.70)	0.93
Nvoxel in ml MCP	1.65 (0.47–6.57)	3.12(0.80–9.22)	1.69(0.00–3.91)	0.56
IRE x Nvoxel in ml wrist	0.15 (0.05–0.67)	0.25(0.04–0.67)	0.19(0.06–0.56)	0.91
IRE x Nvoxel in ml MCP	0.02 (0.002–0.15)	0.06(0.003–0.24)	0.006(0.00–0.07)	0.31
ME x Nvoxel in ml wrist	21.43(9.76–62.29)	26.65(10.09–56.40)	26.73(14.72–42.67)	0.92
ME x Nvoxel in ml MCP	2.30 (0.67–14.23)	6.70(0.91–21.34)	2.46(0.00–7.42)	0.50
IRE x ME wrist	0.02 (0.01–0.05)	0.03(0.01–0.06)	0.02(0.01–0.05)	0.87
IRE x ME MCP	0.03 (0.01–0.09)	0.04(0.01–0.12)	0.01(0.00–0.05)	0.21
Mean changes
Δ Nvoxel in ml wrist	− 2.22 (− 4.84;0.41)	− 2.47(− 6.93;1.99)	− 2.87(− 10.37;4.63)	0.98
Δ Nvoxel in ml MCP	− 1.99 (− 3.02;-0.96)	− 1.72(− 3.47;0.03)	−0.79 (− 3.74;2.17)	0.74
Δ IRE x Nvoxel in ml wrist	−0.18(− 0.28;-0.07)	−0.11(− 0.29;0.07)	−0.17(− 0.46;0.13)	0.80
Δ IRE x Nvoxel in ml MCP	−0.07 (− 0.11;-0.03)	−0.06(− 0.13;0.003)	−0.06(− 0.17;0.06)	0.99
Δ ME x Nvoxel in ml wrist	−7.72 (− 14.69;-0.76)	−5.55(− 17.37;6.27)	−7.90(− 27.80;12.00)	0.95
Δ ME x Nvoxel in ml MCP	−5.17(− 7.42;-2.92)	− 4.82(− 8.64;-1.00)	−3.12(− 9.58;3.33)	0.84
Δ IRE x ME wrist	−0.01 (− 0.02;− 0.01)	−0.01(− 0.02;0.003)	-0.01(− 0.03;0.01)	0.81
Δ IRE x ME MCP	− 0.03(− 0.04;-0.02)	−0.03(− 0.06;-0.01)	−0.03(− 0.07;0.01)	0.96

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