The course of pain hypersensitivity according to painDETECT in patients with rheumatoid arthritis initiating treatment: results from the prospective FRAME-cohort study

Table 4 Multivariable regression models examining change expressed as least squares means (95% CI)

Protocolized models	PDQ score < 13	PDQ score 13–18	PDQ score > 18	p value
Unadjusted model
ΔDAS28	−1.30(− 1.64;-0.97)	−1.17(− 1.74;-0.60)	− 2.08(− 3.06;-1.10)	0.27
ΔRAMRIS Synovitis	−1.68(− 2.30;-1.06)	−1.75(− 2.80;-0.70)	−2.46(− 4.25;-0.66)	0.72
ΔVAS pain	−17.57(− 24.13;-11.02)	− 25.45(− 36.56;-14.33)	−38.13(− 57.15;-19.11)	0.09
Adjusted
ΔDAS28	−1.49 (− 1.81;-1.18)	−1.16(− 1.70;-0.61)	−2.06(− 2.94;-1.17)	0.17
ΔRAMRIS Synovitis	−1.78(− 2.44;-1.26)	−1.72(− 2.86;-0.57)	−2.48(− 4.34;-0.63)	0.74
ΔVAS pain	− 19.36(− 25.89;-12.83)	−24.71(− 36.07;-13.35)	−38.04(− 56.50;-19.56)	0.15

No interaction was found in any of the models. The protocolized unadjusted models included the baseline PDQ classification groups as a trichotomous variable and RAMRIS synovitis score for the hand. The adjusted models further included female sex, disease duration, initiation group, and DAS28-CRP as covariates
Protocolized models, n: PDQ score < 13; n = 51, PDQ score 13–18; n = 18, PDQ score > 18; n = 6

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