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Table 4 Multivariable regression models examining change expressed as least squares means (95% CI)

From: The course of pain hypersensitivity according to painDETECT in patients with rheumatoid arthritis initiating treatment: results from the prospective FRAME-cohort study

Protocolized models PDQ score < 13 PDQ score 13–18 PDQ score > 18 p value
Unadjusted model
 ΔDAS28 −1.30(− 1.64;-0.97) −1.17(− 1.74;-0.60) − 2.08(− 3.06;-1.10) 0.27
 ΔRAMRIS Synovitis −1.68(− 2.30;-1.06) −1.75(− 2.80;-0.70) −2.46(− 4.25;-0.66) 0.72
 ΔVAS pain −17.57(− 24.13;-11.02) − 25.45(− 36.56;-14.33) −38.13(− 57.15;-19.11) 0.09
Adjusted
 ΔDAS28 −1.49 (− 1.81;-1.18) −1.16(− 1.70;-0.61) −2.06(− 2.94;-1.17) 0.17
 ΔRAMRIS Synovitis −1.78(− 2.44;-1.26) −1.72(− 2.86;-0.57) −2.48(− 4.34;-0.63) 0.74
 ΔVAS pain − 19.36(− 25.89;-12.83) −24.71(− 36.07;-13.35) −38.04(− 56.50;-19.56) 0.15
  1. No interaction was found in any of the models. The protocolized unadjusted models included the baseline PDQ classification groups as a trichotomous variable and RAMRIS synovitis score for the hand. The adjusted models further included female sex, disease duration, initiation group, and DAS28-CRP as covariates
  2. Protocolized models, n: PDQ score < 13; n = 51, PDQ score 13–18; n = 18, PDQ score > 18; n = 6