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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Upper zone of growth plate and cartilage matrix associated protein protects cartilage during inflammatory arthritis

Fig. 2

Ucma is expressed in the articular cartilage and in osteophytes during arthritis. a Representative immunohistochemical stainings of Ucma in articular cartilage of metatarsal joints from non-arthritic control mice (Ctrl.), and WT (SIA/WT) and Ucma-deficient (SIA/KO) mice with serum-induced arthritis (SIA). b Quantification of Ucma-positive chondrocytes (n = 5/group). Means ± SEM shown. c Representative immunohistochemical staining of Ucma on hind paw section from WT mouse with SIA shows Ucma protein in growing osteophyte at the calcaneus. H&E staining on a consecutive section shown for orientation. RNA in-situ hybridisation for collagen10a1 (Col10a1) on a consecutive section indicates presence of hypertrophic chondrocytes adjacent to Ucma-positive chondrocytes at the calcaneus. a, c Composite images of 4–16 individual micrographs, respectively. H&E hematoxylin and eosin, KO knock-out, Ucma Upper zone of growth plate and cartilage matrix-associated protein, Ucma−/− Ucma-deficient, WT wild type

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