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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Upper zone of growth plate and cartilage matrix associated protein protects cartilage during inflammatory arthritis

Fig. 6

Reduced osteoblast and osteoclast numbers in arthritic Ucma-deficient mice. a RNA in-situ hybridisation for collagen10a1 in hind paw sections of wild-type (WT) and Ucma-deficient (Ucma−/−) mice with serum-induced arthritis (SIA) Higher magnification inserts shown for mice with SIA. b Histomorphometric quantification of collagen10a1 (Col10a1)-positive regions in osteophytes (maximal absolute collagen10a1-positive osteophyte area (Col10a1 pos. Ar.)). c RNA in-situ hybridisation for osteocalcin (Ocn). c′ Inserts with higher magnification. d Histomorphometric quantification of Ocn-positive osteoblasts (osteoblast numbers per bone perimeter (N.Ob./B.Pm.)). e TRAP staining for osteoclasts. e′ Inserts with higher magnification. f Histomorphometric quantification of TRAP-positive osteoclast numbers per bone perimeter in the hind paws (N.Oc./B.Pm). g Histomorphometric quantification of osteoclast surface/bone surface in the hind paws (Oc.S/B.S.). Means ± SEM shown; n = 7 or 8 per group. a, c, e Composite images of 12–20 individual micrographs, respectively. Ctrl./WT non-arthritic WT control, Ctrl./KO non-arthritic Ucma-deficient control, KO knock-out, SIA/WT WT with SIA, SIA/KO Ucma-deficient with SIA, Ucma Upper zone of growth plate and cartilage matrix-associated protein

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