Fig. 4

Fcγ receptor (FcγR)I,II,III,IV^−/− mice have decreased inflammation in arthritic joints. Photomicrographs of H&E staining showing the infiltrate and exudate in knee joints of wild-type (WT) and FcγRI,II,III,IV^−/− mice at days 7 and 21 of antigen-induced arthritis (AIA). Original magnification ×100. Quantification showed decreased infiltrate and exudate in the knee joints of FcγRI,II,III,IV^−/− mice compared with WT controls at day 7 of AIA. In contrast, no differences were observed at day 21 (n = 24 and n = 17 joints per time point for WT and FcγRI,II,III,IV^−/− mice, respectively). Scatterplots are shown, with horizontal and vertical lines representing mean ± SEM values. ns Not significant. * P < 0.05, ** P < 0.01