Fig. 5

Prominent role for Fcγ receptor (FcγR)IV in regulating the influx of neutrophils into the joint. a NIMPR14-positive area, percentage of NIMPR14-positive area in the infiltrate, and number of NIMPR14-positive cells in the exudate are decreased in FcγRI,II,III,IV^−/− mice compared with wild-type (WT) mice in day 7 antigen-induced arthritis (AIA). b Comparable numbers of F4/80-positive cells are present in the joints of FcγRI,II,III,IV^−/− mice compared with their WT controls at day 7 AIA. c In contrast to FcγRI,II,III,IV^−/− mice, the total NIMPR14-positive area, percentage of NIMPR14-positive area in the infiltrate, and number of NIMPR14-positive cells in the exudate are increased in FcγR I,II,III^−/− mice. d Comparable numbers and reduced percentage of F4/80-positive cells in the joint of FcγR I,II,III^−/− mice compared with their WT controls at day 7 of AIA. Scatterplots are shown, with horizontal and vertical lines representing mean ± SEM values of at least six mice per group. ns Not significant. * P < 0.05, ** P < 0.01