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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Fcγ receptor-mediated influx of S100A8/A9-producing neutrophils as inducer of bone erosion during antigen-induced arthritis

Fig. 6

The number of S100A8-producing neutrophils correlates with the severity of bone erosion during antigen-induced arthritis. a S100a8 messenger RNA levels in the synovium of Fcγ receptor (FcγR)I,II,III,IV−/− mice are decreased compared with wild-type (WT) mice at day 7 of antigen-induced arthritis (AIA). b Representative photomicrographs show S100A8 staining in knee joint sections of WT and FcγRI,II,III,IV−/− mice at day 7 of AIA. Original magnification ×100 and ×400. Quantification showed a decreased number of S100A8-positive cells in FcγRI,II,III,IV−/− mice compared with their WT controls. c A significant correlation was observed between the number of neutrophils (NIMPR14-positive cells) in the infiltrate and exudate in the joint and bone erosion in both WT and FcγRI,II,III,IV−/− mice at day 7 of AIA. d A significant correlation between the number of S100A8-positive cells in the joint and the severity of bone erosion in both WT and FcγRI,II,III,IV −/− mice at day 7 of AIA was found. * P < 0.05. rs = Spearman’s rank correlation coefficient

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