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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women

Fig. 2

Effects of estrogen on Fcγ receptor expression. Ovariectomized (OVX) mice at 3 months of age followed by insertion of slow-release treatment pellets with placebo (Pla) or estrogen (E2; 0.83 μg/day). Ten days after ovariectomy, the animals were immunized with ovalbumin (OVA), and 14 days later, they were boostered. On day 38, mean fluorescence intensity (MFI) of Fc receptors (FcRs) was quantified using flow cytometry in all leukocytes as well as B cells, plasmablasts, monocytes, and neutrophils. Expression of inhibitory FcγRIIb in (a) bone marrow cells and (b) spleen cells. Expression of stimulatory FcγRIII and FcγRIV in (c) bone marrow cells and (d) spleen cells. Groups are presented with a bar indicating mean ± SEM (n = 6–7). Statistical analysis with analysis of variance followed by the Bonferroni multiple-comparisons test for selected time points. *p < 0.05, **p < 0.01, ***p < 0.001

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Arthritis Research & Therapy

ISSN: 1478-6362

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