Table 2 Influence of the invasion of pannus in the cartilage area on cartilaginous structures and related inflammation expression
Pannus invasion (N = 26) | No pannus invasion (N = 24) | P | |
|---|---|---|---|
Cartilage | |||
Chondrocyte degeneration, n (%) | 20 (76.9) | 5 (20.8) | 0.000 |
Cartilage matrix degeneration, n (%) | 23 (88.5) | 9 (37.5) | 0.000 |
Endochondral ossification, n (%) | 10 (38.5) | 5 (20.8) | 0.174 |
VEGF | |||
Scores | 2.0 ± 1.3 | 1.1 ± 1.2 | 0.021 |
Area of positive expression (μm2) | 657.4 ± 984.9 | 199.3 ± 418.8 | 0.022 |
Caspase-3 | |||
Scores | 2.3 ± 0.9 | 1.8 ± 1.7 | 0.419 |
Area of positive expression (μm2) | 620.0 ± 652.5 | 207.7 ± 285.2 | 0.185 |
MMP-3 | |||
Scores | 2.0 ± 1.1 | 0.7 ± 0.8 | 0.010 |
Area of positive expression (μm2) | 378.4 ± 406.0 | 50.3 ± 83.3 | 0.008 |
TNF-α | |||
Scores | 3.2 ± 1.2 | 1.6 ± 1.0 | 0.012 |
Area of positive expression (μm2) | 846.9 ± 739.2 | 181.1 ± 172.8 | 0.025 |
Bone-cartilage interface (n/40 hpf) | |||
CD34+ microvessels | 12.7 ± 3.6 | 7.4 ± 2.0 | 0.000 |
CD68+ macrophages | 10.1 ± 2.9 | 8.7 ± 3.5 | 0.277 |
CD68+ multinuclear osteoclasts | 2.3 ± 0.9 | 1.9 ± 0.9 | 0.228 |