Fig. 5

Schematic of chemerin cleavages. Chem163S (pink box) can be cleaved either by factor XIa (FXIa), Plasmin, or Tryptase generating chem158K (pink box), by elastase generating a mixture of chem157S (red box) and chem155A (blue box), by chymase generating chem156F (dark pink box), or by proteinase 3 and Tryptase generating chem155A. chem158K can then be cleaved by carboxypeptidase B2 (CPB2) or carboxypeptidase N (CPN) to form active chem157S, which is subsequently inactivated by angiotensin-converting enzyme (ACE) forming inactive chem155A