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Table 1 Association of latitude with dermatomyositis prevalence, dermatomyositis-specific autoantibody and associated human leucocyte antigen allele frequency

From: Genetic background may contribute to the latitude-dependent prevalence of dermatomyositis and anti-TIF1-γ autoantibodies in adult patients with myositis

Variable Associations with latitude, adjusted for sex
OR (95% CI) P value
Relative prevalence of DM 0.96 (0.95, 0.98) < 0.001
Anti-Mi-2 0.99 (0.97, 1.03) 0.927
Anti-TIF1-γ 0.95 (0.92, 0.99) 0.004
HLA-DRB1*07:01 (associated with anti-Mi-2) 0.97 (0.96, 0.98) < 0.001
HLA-DQB1*02 (associated with anti-TIF1-γ) 0.98 (0.97, 0.99) < 0.001
  1. DM Dermatomyositis, HLA Human leucocyte antigen, TIF1-γ Transcription intermediary factor 1
  2. All variables were analysed against latitude in an ordered logistic regression analysis, adjusted for sex. Relative prevalence of DM was calculated as the frequency of DM/the frequency of polymyositis (PM) and DM combined. The proportion of autoantibodies was calculated from all adult PM and DM cases tested for that particular autoantibody (n = 1471 tested for anti-Mi-2, n = 1345 tested for anti-TIF1-γ), derived from case data in the Immunochip study (n = 1769). HLA allele frequencies were calculated from the Immunochip control data (n = 9911) for DM-specific autoantibody associations in the Immunochip data (HLA-DRB1*07:01 with anti-Mi-2 and HLA-DQB1*02 with anti-TIF1-γ, P = 4.36 × 10− 12 and P = 2.11 × 10− 11, respectively [11]; Rothwell S: Personal communication, in preparation)