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Table 2 Association of polymyositis- or dermatomyositis-associated single-nucleotide polymorphisms with latitude

From: Genetic background may contribute to the latitude-dependent prevalence of dermatomyositis and anti-TIF1-γ autoantibodies in adult patients with myositis

Variable Immunochip associations and P values for subgroups Associations with latitude, adjusted for sex
Reported gene Polymyositis Dermatomyositis OR (95% CI) P value
PM associations
 rs2476601 PTPN22 7.90 × 10−11 0.05 1.08 (1.05, 1.11) < 0.001
 rs4690220 SLC26A1 | IDUA 7.47 × 10−6 0.03 1.02 (1.01, 1.02) 0.001
 rs7956536 UBE3B | MMAB 3.66 × 10−6 0.67 1.01 (1.00, 1.02) 0.004
 rs17799348 FAM167A | BLK 4.13 × 10−6 0.32 0.99 (0.98, 0.99) 0.035
 rs1420095 IL18R1 6.16 × 10−6 0.87 0.99 (0.98, 1.01) 0.334
 rs2286896 NAB1 3.76 × 10−6 0.58 0.99 (0.98, 1.01) 0.434
 rs9905921 LOC728073 | RPL38 2.01 × 10−6 0.10 0.99 (0.99, 1.01) 0.748
 rs7535818 RGS1 1.37 × 10−5 0.14 0.99 (0.99, 1.01) 0.897
DM associations
 rs4702698 ROPN1L | ANKRD33B 0.5 4.49 × 10−6 0.99 (0.98, 0.99) 0.012
 rs570676 PRR5L | TRAF6 0.01 6.23 × 10−7 0.99 (0.98, 1.00) 0.081
  1. DM Dermatomyositis, PM Polymyositis
  2. All variables were analysed against latitude in an ordered logistic regression analysis, adjusted for sex. Single-nucleotide polymorphisms (SNPs) identified as having suggestively significant P values (P < 2.25 × 10−5) for either PM or DM in the Immunochip study [8] were used. SNP risk allele frequencies were calculated from the Immunochip study control data (n = 9911)