|
Variable
|
Immunochip associations and P values for subgroups
|
Associations with latitude, adjusted for sex
|
|---|
|
Reported gene
|
Polymyositis
|
Dermatomyositis
|
OR (95% CI)
|
P value
|
|---|
|
PM associations
|
|
rs2476601
|
PTPN22
|
7.90 × 10−11
|
0.05
|
1.08 (1.05, 1.11)
|
< 0.001
|
|
rs4690220
|
SLC26A1 | IDUA
|
7.47 × 10−6
|
0.03
|
1.02 (1.01, 1.02)
|
0.001
|
|
rs7956536
|
UBE3B | MMAB
|
3.66 × 10−6
|
0.67
|
1.01 (1.00, 1.02)
|
0.004
|
|
rs17799348
|
FAM167A | BLK
|
4.13 × 10−6
|
0.32
|
0.99 (0.98, 0.99)
|
0.035
|
|
rs1420095
|
IL18R1
|
6.16 × 10−6
|
0.87
|
0.99 (0.98, 1.01)
|
0.334
|
|
rs2286896
|
NAB1
|
3.76 × 10−6
|
0.58
|
0.99 (0.98, 1.01)
|
0.434
|
|
rs9905921
|
LOC728073 | RPL38
|
2.01 × 10−6
|
0.10
|
0.99 (0.99, 1.01)
|
0.748
|
|
rs7535818
|
RGS1
|
1.37 × 10−5
|
0.14
|
0.99 (0.99, 1.01)
|
0.897
|
|
DM associations
|
|
rs4702698
|
ROPN1L | ANKRD33B
|
0.5
|
4.49 × 10−6
|
0.99 (0.98, 0.99)
|
0.012
|
|
rs570676
|
PRR5L | TRAF6
|
0.01
|
6.23 × 10−7
|
0.99 (0.98, 1.00)
|
0.081
|
- DM Dermatomyositis, PM Polymyositis
- All variables were analysed against latitude in an ordered logistic regression analysis, adjusted for sex. Single-nucleotide polymorphisms (SNPs) identified as having suggestively significant P values (P < 2.25 × 10−5) for either PM or DM in the Immunochip study [8] were used. SNP risk allele frequencies were calculated from the Immunochip study control data (n = 9911)
