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Table 1 Demographic and disease-specific characteristics of patients with nonradiographic axial spondyloarthritis and healthy control subjects

From: Cortical bone loss is an early feature of nonradiographic axial spondyloarthritis

 

Nr-axSpA

(n = 101)

Control subjects

(n = 50)

p Value

Demographic characteristics

 Female sex, n (%)

42 (41.6)

20 (40)

0.852

 Age, yr

45.0 (15.0)

44.76 (26.0)

0.917

 Height, m

1.74 (0.1)

1.74 (0.1)

0.997

 Weight, kg

81.1 (21.5)

76.0 (18.5)

0.054

 Body mass index, kg/m2

26.3 (6.5)

23.8 (5.2)

0.118

 Current or previous smoking, n (%)

38 (37.6)

11 (24.4)

0.119

Disease-specific characteristics

 HLA-B27 positivity, n (%)

75 (75.0)

 Duration of disease, yr

6.5 (9.0)

 Disease remission, n (%)

15 (14.9)

 ASDAS-CRP, units

2.1 (1.4)

 BASDAI, units

3.5 (3.6)

 C-reactive protein, mg/L

6.2 (4.0)

 ESR, mm

12.7 (10.5)

 BASFI, units

2.9 (3.8)

 BASMI, units

1.1 (2)

 Peripheral arthritis, n (%)

35 (34.7)

 Dactylitis, n (%)

2 (2.0)

 Enthesitis, n (%)

17 (16.8)

 MASES, units

1.1 (1)

 Psoriasis, n (%)

13 (12.9)

 Uveitis, n (%)

8 (7.9)

 Inflammatory bowel disease, n (%)

7 (6.9)

 Low trauma fracture, n (%)

7 (6.9)

 25(OH)vitamin D3, ng/ml

32.4 (16.3)

Treatment modalities

 Current biologic therapya, n (%)

59 (58.4)

 Duration of biologic therapy, yr

2.0 (4.0)

  

 Current DMARD therapyb, n (%)

28 (27.7)

 NSAID, n (%)

68 (67.3)

 NSAID daily, n (%)

22 (21.8)

 NSAID on demand, n (%)

46 (45.5)

 Prednisolone ≥ 5 mg > 3 monthsc, n (%)

32 (31.7)

 Calcium substitution, n (%)

8 (7.9)

 25(OH)vitamin D3 substitution, n (%)

26 (25.7)

 Antiresorptive treatment, n (%)

5 (5.0)

  1. Abbreviations: axSpA Axial spondyloarthritis, ESR Erythrocyte sedimentation rate, 25(OH)vitamin D3 25-Hydroxyvitamin D3, ASDAS-CRP Ankylosing Spondylitis Disease Activity Score, defined as inactive < 1.3, moderate < 2.1, high < 3.5, very high > 3.5 disease activity, disease remission defined as ASDAS-CRP < 1.3, BASDAI Bath Ankylosing Spondylitis Disease Activity Index, BASFI Bath Ankylosing Spondylitis Functional Index, BASMI Bath Ankylosing Spondylitis Metrology Index, MASES Maastrich Ankylosing Spondylitis Enthesitis Score, DMARD Disease-modifying antirheumatic drug, NSAID Nonsteroidal anti-inflammatory drug
  2. Results are median (IQR) or absolute value and percent
  3. aTumor necrosis factor inhibitors
  4. bMethotrexate, sulfasalazine, azathioprine, leflunomide, mesalazine
  5. cHistory of treatment with ≥ 5 mg prednisolone for ≥ 3 months