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Table 3 Bone microstructure in patients with nonradiographic axial spondyloarthritis with short and longer disease duration and in healthy control subjects

From: Cortical bone loss is an early feature of nonradiographic axial spondyloarthritis

  axSpA <  2 yr (n = 46) axSpA >  2 yr (n = 55) Control subjects (n = 50) axSpA < 2 yr vs. axSpA > 2 years vs. control subjects axSpA < 2 yr vs. control subjects axSpA < 2 yr vs. axSpA > 2 yr axSpA > 2 yr vs. control subjects
Bone geometry
 Total bone area, mm2 317 (114) 349 (94) 326 (116) 0.060 0.322 0.023 0.136
 Ct. area, mm2 59 (18) 61 (22) 65 (23) 0.068 0.032 0.703 0.066
 Tb. area, mm2 250 (95) 277 (88) 254 (83) 0.068 0.628 0.041 0.062
Volumetric bone mineral density
 Total BMD, HA/cm3 317 (49) 309 (75) 334 (61) 0.096 0.170 0.423 0.036
 Ct. BMD, HA/cm3 833 (62) 814 (65) 846 (78) 0.012 0.096 0.167 0.004
 Tb. BMD, HA/cm3 173 (44) 175 (47) 183 (68) 0.571 0.289 0.564 0.610
 Tb. meta BMD, HA/cm3 233 (38) 234 (51) 243 (61) 0.561 0.294 0.728 0.465
 Tb. inn BMD, HA/cm3 132 (47) 135 (52) 141 (72) 0.618 0.359 0.464 0.753
Bone microstructure
 BV/TV, % 14.4 (3.7) 14.6 (3.9) 15.2 (5.7) 0.575 0.288 0.564 0.628
 Tb. N, mm− 1 2.12 (0.30) 2.05 (0.41) 2.11(0.42) 0.534 0.739 0.263 0.480
 Tb. Th, μm 68 (15) 71 (15) 72 (17) 0.244 0.171 0.120 0.946
 Tb. Sp, μm 410 (66) 423 (107) 410 (104) 0.677 0.956 0.480 0.424
 Inhomogeneity, μm 165 (41) 178 (48) 169 (47) 0.351 0.575 0.149 0.399
 Ct. Th, μm 775 (160) 759 (235) 840 (160) 0.015 0.050 0.245 0.007
 Ct. Po, % 2.0 (1.46) 2.8 (1.72) 2.2 (1.57) 0.064 0.373 0.020 0.157
  1. Abbreviations: BMD Bone mineral density, SpA Spondyloarthritis, Ct. Cortical, Tb. Trabecular, Tb. meta Bone mineral density peripheral trabecular density adjacent to cortex, Tb. inn Bone mineral density central medullary trabecular density, BV/TV Trabecular bone volume, Th Thickness, Sp Separation, Po Porosity
  2. Bone geometry, microstructure, and volumetric BMD by high-resolution peripheral quantitative computed tomography at the ultradistal radius. Results are median (IQR)
  3. Bold indicates significant differences (p < 0.05)