Table 1 SNPs associated with serum urate levels and habitual coffee intake in previous GWAS using participants of European ancestry

Coffee GWAS [20]

SNP

rs1260326

rs1481012

rs7800944

rs2472297

Chr: Position (B37)

2:27730940

4:89039082

7:73035857

15:75027880

Effect allele/other

T/C

A/G

T/C

T/C

Effect allele freq.

0.41

0.89

0.72

0.24

Beta (cups/day)

−0.04

0.06

−0.05

0.15

SE

0.01

0.01

0.01

0.01

P

1.06 × 10⁻⁷

1.13 × 10⁻⁶

7.82 × 10⁻⁹

6.45 × 10⁻⁴⁷

Urate GWAS [2]

SNP

rs1260326

rs2231142

rs1178977

rs2472297

Chr: Position (B37)

2:27730940

4:89271347

7:72494985

15:75027880

Effect allele/other

T/C

G/T

A/G

T/C

Effect allele freq.

0.41

0.89

0.81

0.24

Beta (mg/dl)

0.07

−0.22

0.05

−0.03

SE

0.01

0.01

0.01

0.01

P

1.20 × 10⁻⁴⁴

1.00 × 10⁻¹³⁴

1.20 × 10⁻¹²

3.85 × 10⁻⁶

LD

Euro r²

Same SNP

0.94

0.58

Same SNP

rs2231142: T

rs1178977: G

rs1481012: G

rs7800944: C

UKBB r²

Same SNP

0.99

0.57

Same SNP

rs2231142: T

rs1178977: G

rs1481012: G

rs7800944: C