From: Mediation analysis to understand genetic relationships between habitual coffee intake and gout
 |  | Association of coffee intake (any coffee) with gout | ||
Observations | Odds ratio | 95% confidence interval | P | |
Unadjusted | 130,731 | 0.85 | 0.77–0.94 | 0.002 |
Adjusted†| 121,897 | 0.75 | 0.67–0.84 | 9.05 × 10−7 |
Adjusted†including beer/spirits | 86,676 | 0.75 | 0.66–0.86 | 1.40 × 10−5 |
 |  | Association of coffee intake (per cup per day) with gout | ||
Observations | Odds ratio | 95% confidence Interval | P | |
Unadjusted | 130,731 | 0.91 | 0.89–0.93 | 3.08 × 10−15 |
Adjusted†| 121,897 | 0.85 | 0.82–0.87 | 8.55 × 10−32 |
Adjusted†including beer/spirits | 86,676 | 0.85 | 0.83–0.88 | 1.09 × 10−23 |