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Table 4 Association analysis of urate-associated SNPs with gout and coffee intake

From: Mediation analysis to understand genetic relationships between habitual coffee intake and gout

   

Association of gout with urate-associated SNPs

Association of coffee intake (cups per day) with urate-associated SNPs

Gene

SNP

Effect allele

Observations

%

Odds ratio

95% Confidence interval

P

Observations

%

Unadjusted β coefficient

95% Confidence

interval

P

GCKR

 Unadjusted

rs1260326

T

130,966

100.0%

1.40

1.27–1.53

3.34 × 10−12

130,731

100.0%

−0.07

−0.10 to −0.05

1.33 × 10−8

 Adjusted†

121,940

93.1%

1.43

1.29–1.58

4.05 × 10−12

121,897

93.2%

−0.08

−0.10 to −0.05

3.05 × 10−10

 Adjusted† including beer/spirits

86,702

66.2%

1.45

1.30–1.62

2.32 × 10−11

86,676

66.3%

−0.07

−0.10 to −0.05

2.47 × 10−8

ABCG2

 Unadjusted

rs2231142

T

130,966

100.0%

2.26

2.07–2.47

1.05 × 10−72

130,731

100.0%

−0.07

−0.10 to −0.04

1.00 × 10−6

 Adjusted†

121,940

93.1%

2.37

2.15–2.61

6.62 × 10−69

121,897

93.2%

−0.09

−0.11 to −0.06

2.10 × 10−9

 Adjusted† including beer/spirits

86,702

66.2%

2.45

2.20–2.72

4.78 × 10−61

86,676

66.3%

−0.08

−0.11 to −0.05

3.99 × 10−7

MLXIPL

 Unadjusted

rs1178977

A

130,966

100.0%

1.25

0.98–1.61

0.07

130,702

100.0%

−0.15

−0.21 to −0.09

3.00 × 10−6

 Adjusted†

121,940

93.1%

1.24

0.95–1.61

0.11

121,897

93.2%

−0.17

−0.23 to −0.11

3.20 × 10−8

 Adjusted† including beer/spirits

86,702

66.2%

1.24

0.94–1.65

0.13

86,661

66.3%

−0.21

−0.27 to −0.14

5.45 × 10−10

CYP1A2

 Unadjusted

rs2472297

C

130,966

100.0%

1.15

0.96–1.37

0.13

130,731

100.0%

−0.25

−0.30 to −0.21

3.02 × 10−26

 Adjusted†

121,940

93.1%

1.16

0.96–1.40

0.12

121,897

93.2%

−0.30

−0.35 to −0.26

7.61 × 10−40

 Adjusted† including beer/spirits

86,702

66.2%

1.16

0.94–1.42

0.17

86,676

66.3%

−0.30

−0.35 to −0.25

2.80 × 10−32

  1. Analysis is shown for the presence of at least one urate-raising allele
  2. Effect allele is allele associated with hyperuricaemia in Kottgen GWAS paper [2]
  3. SNP single nucleotide polymorphism
  4. †Adjusted for age, sex, body mass index, hypertension, kidney disease, diabetes, meat intake, fish intake, cheese intake, tea intake, fruit intake, vegetable intake, bread intake, and cereal intake
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Arthritis Research & Therapy

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