TY - JOUR AU - Korman, Benjamin AU - Marangoni, Roberta Goncalves AU - Lord, Gabriel AU - Olefsky, Jerrold AU - Tourtellotte, Warren AU - Varga, John PY - 2018 DA - 2018/07/11 TI - Adipocyte-specific Repression of PPAR-gamma by NCoR Contributes to Scleroderma Skin Fibrosis JO - Arthritis Research & Therapy SP - 145 VL - 20 IS - 1 AB - A pivotal role for adipose tissue homeostasis in systemic sclerosis (SSc) skin fibrosis is increasingly recognized. The nuclear receptor PPAR-γ is the master regulator of adipogenesis. Peroxisome proliferator activated receptor-γ (PPAR-γ) has antifibrotic effects by blocking transforming growth factor-β (TGF-β) and is dysregulated in SSc. To unravel the impact of dysregulated PPAR-γ in SSc, we focused on nuclear corepressor (NCoR), which negatively regulates PPAR-γ activity and suppresses adipogenesis. SN - 1478-6362 UR - https://doi.org/10.1186/s13075-018-1630-z DO - 10.1186/s13075-018-1630-z ID - Korman2018 ER -