Fig. 1
From: Adipocyte-specific Repression of PPAR-gamma by NCoR Contributes to Scleroderma Skin Fibrosis
Differential expression of nuclear corepressor (NCoR)-modulated genes in systemic sclerosis (SSc). a Skin biopsy transcriptomes from 70 patients with SSc and 22 healthy control subjects [GEO:GSE76886] were queried for expression of genes negatively regulated by NCoR. Hierarchical clustering identified three subsets: cluster 1, a small subset with significant NCoR upregulation and comprised mostly of patients with SSc; cluster 2, a subset made mostly of control individuals; and cluster 3, a group of patients with SSc with decreased NCoR-mediated expression. These clusters distinguish SSc biopsies from controls (p < 0.0001 by chi-square test). The number and percentage of biopsies are denoted for each group. Red indicates gene upregulation; green indicates downregulation. b NCoR pathway scores were determined (see the Methods section for derivation). Note the significantly elevated scores in SSc skin biopsies. c and d NCoR pathway scores correlate significantly with peroxisome proliferator activated receptor-γ (PPAR-γ) and transforming growth factor-β (TGF-β) pathway scores. e Correlation of NCoR pathway scores and the modified Rodnan skin score (MRSS)