Fig. 1
From: The roles of neutrophil serine proteinases in idiopathic inflammatory myopathies
Expression of CTSG, NE, and PR3 in DM/PM and their methylation. Relative expression of CTSG, NE, and PR3 increased in DM and PM PBMCs compared to controls at RNA level (a–c). CTSG, NE, and PR3 hypomethylated in PBMCs of DM/PM patients (d–f). No significant difference in serum levels of CTSG in DM, PM, and controls (g). Serum levels of NE and PR3 higher in DM patients and PR3 higher in PM patients than in controls (h, i). Values are mean ± SEM. CTSG cathepsin G, DM dermatomyositis, GAPDH glycerol-3-phosphate dehydrogenase, NC normal control, NE neutrophil elastase, PM polymyositis, PR3 proteinase 3