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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivo

Fig. 3

Development of osteoarthritis in Dunkin-Hartley guinea pigs. a Total OA score at four sites in each group. b Global synovial histological score in each group. Horizontal bars indicate median values. c Correlation of global synovial histological score with total OA score (r = 0.55, p = 7 × 10− 6; Spearman). Thickness (in millimeters) (d and e) and instantaneous modulus (MPa) (f and g) in femoral condyles and tibial plateau, respectively. Data are mean ± SEM (n = 12 in each group, except n = 10 at week 36). h–k Correlations of cartilage thickness and instantaneous modulus on global OA histological score in condyle and tibial plateau. Correlation coefficients are (h) r = − 0.35, p < 0.01; (i) r = − 0.27, p < 0.05; (j) r = 0.58, p < 0.001; and (k) r = 0.44, p < 0.002. Significance (a–f): * p < 0.05; ** p < 0.01; and *** p < 0.001 with respect to 4-week study group; o, oo, and ooo, p < 0.05, p < 0.01, and p < 0.001 with respect to 12-week study group; and # p < 0.05 with respect to 20-week study group; one-way analysis of variance with Tukey posttest

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