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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivo

Fig. 5

Concentrations of glycation, oxidation, and nitration free adducts in multilayer culture supernatant. Analyte concentrations in the culture medium, normalized to cell DNA content. Key: dashed lines = control; solid lines = + IL-1β. Free adduct: a FL. b CML. c CEL. d G-H1. e MG-H1. f CMA. g GSP. h AASA. i GSA. j DT. k NFK. l 3-NT. Data are mean ± SEM (n = 4). * p < 0.05, ** p < 0.01, and *** p < 0.001. Through longitudinal statistical study, we found that all biomarkers increased significantly over time (p < 0.0001). Comparison of the time-course curves showed that levels of G-H1, CEL, and 3-NT were increased with IL-1β treatment compared with control (p = 0.0023, p = 0.0071, and p < 0.0001, respectively)

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Arthritis Research & Therapy

ISSN: 1478-6362

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