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Table 1 Correlation of glycation, oxidation, and nitration free adducts and citrullinated protein with global histological score and joint biomechanical properties measured by Mach-1 parameters

From: Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivo

 

Global histological score

Thickness

Instantaneous modulus

Condyle

Plateau

Condyle

Plateau

r

p Value

r

p Value

r

p Value

r

p Value

r

p Value

Glycation

FL

0.33

0.012

      

0.30

0.031

G-H1

0.26

0.046

        

CMA

      

− 0.32

0.017

  

3DG-H

0.27

0.044

        

GSP

0.58

< 0.0001a

    

0.52

< 0.0001a

0.56

< 0.0001a

Oxidation

AASA

0.38

0.0029a

    

0.27

0.043

0.40

0.004

GSA

0.36

0.0062a

− 0.29

0.033

− 0.33

0.015

  

0.35

0.013

Dityrosine

0.42

0.0009a

    

0.34

0.010

0.36

0.010

NFK

0.42

0.0011a

    

0.37

0.006

0.33

0.018

Nitration

3-NT

− 0.46

0.0003a

0.33

0.013

0.29

0.034

− 0.46

0.0004a

− 0.41

0.003a

Hyp

  

0.47

0.0003a

0.39

0.003a

− 0.38

0.0037

  

CP

− 0.52

< 0.0001a

    

− 0.53

< 0.0001a

− 0.33

0.018

  1. Abbreviations: FL Nε-fructosyl-lysine, G-H1 Glyoxal-derived hydroimidazolone, CMA Nω-carboxymethylarginine, 3DG-H 3-Deoxyglucosone-derived hydroimidazolone isomers, GSP Glucosepane, AASA α-Aminoadipic semialdehyde, GSA Glutamic semialdehyde, NFK N-formylkynurenine, 3-NT 3-Nitrotyrosine, Hyp Hydroxyproline, CP Citrullinated protein
  2. aCorrelation coefficient significant after Bonferroni correction of 15 was applied