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Table 1 Correlation of glycation, oxidation, and nitration free adducts and citrullinated protein with global histological score and joint biomechanical properties measured by Mach-1 parameters

From: Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivo

  Global histological score Thickness Instantaneous modulus
Condyle Plateau Condyle Plateau
r p Value r p Value r p Value r p Value r p Value
Glycation FL 0.33 0.012        0.30 0.031
G-H1 0.26 0.046         
CMA        − 0.32 0.017   
3DG-H 0.27 0.044         
GSP 0.58 < 0.0001a      0.52 < 0.0001a 0.56 < 0.0001a
Oxidation AASA 0.38 0.0029a      0.27 0.043 0.40 0.004
GSA 0.36 0.0062a − 0.29 0.033 − 0.33 0.015    0.35 0.013
Dityrosine 0.42 0.0009a      0.34 0.010 0.36 0.010
NFK 0.42 0.0011a      0.37 0.006 0.33 0.018
Nitration 3-NT − 0.46 0.0003a 0.33 0.013 0.29 0.034 − 0.46 0.0004a − 0.41 0.003a
Hyp    0.47 0.0003a 0.39 0.003a − 0.38 0.0037   
CP − 0.52 < 0.0001a      − 0.53 < 0.0001a − 0.33 0.018
  1. Abbreviations: FL Nε-fructosyl-lysine, G-H1 Glyoxal-derived hydroimidazolone, CMA Nω-carboxymethylarginine, 3DG-H 3-Deoxyglucosone-derived hydroimidazolone isomers, GSP Glucosepane, AASA α-Aminoadipic semialdehyde, GSA Glutamic semialdehyde, NFK N-formylkynurenine, 3-NT 3-Nitrotyrosine, Hyp Hydroxyproline, CP Citrullinated protein
  2. aCorrelation coefficient significant after Bonferroni correction of 15 was applied